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Emistat 4mg/5ml (Syrup)

Manufactured by: Healthcare Pharmaceuticals Ltd.

Ondansetron Similar medicine

Emistat is indicated for

  • Post-op nausea
  • vomiting
  • Nausea
  • vomiting associated w/ cancer chemotherapy

Precautions and warnings

Tell your doctor about any medical conditions you have, especially if you have an irregular heartbeat, liver illness, or stomach difficulties, before taking this drug.

Ondansetron has been linked to a heart rhythm disorder. Rarely, major irregular heartbeat and other symptoms such as acute dizziness and fainting can be caused by cardiac rhythm. It requires immediate medical intervention.

If you have certain medical conditions or are taking other drugs that can induce heart rhythm, your risk of heart rhythm may be raised. Tell your doctor or pharmacist about all of your medications and if you have any of the following conditions before taking ondansetron: specific cardiac issues

Low potassium or magnesium levels in the blood might also put you at risk for an irregular heartbeat. If you use certain drugs or have symptoms like intense sweating, diarrhea, or vomiting, your risk may increase. Consult your doctor about how to use ondansetron safely.

This medication may cause dizziness or drowsiness. You may become dizzy or sleepy if you consume alcohol or cannabis. Do not drive, operate machinery, or engage in any other activity that requires attentiveness until you are sure you can do so safely. Alcoholic beverages should be avoided. If you use cannabis, talk to your doctor.

Get up gently while rising from a sitting or laying posture to avoid dizziness and lightheadedness.

Side-effects

  • Headache
  • malaise/fatigue
  • constipation; drowsiness
  • fever
  • dizziness
  • anxiety
  • cold sensation; pruritus
  • rash; diarrhoea; gynaecological disorder
  • urinary retention; elevated transaminase; local inj site reaction (pain
  • redness
  • burning); paresthesia; hypoxia. Rarely: Anaphylaxis
  • angina
  • bronchospasm
  • ECG changes
  • extrapyramidal symptoms
  • grand mal seizure
  • hypokalaemia
  • tachycardia
  • vascular occlusive events.

Drug Interactions

Apomorphine and tramadol are two drugs that may interact with this one.

Many medicines, including dofetilide, pimozide, procainamide, amiodarone, quinidine, sotalol, and macrolide antibiotics like erythromycin, might influence heart rhythm in addition to ondansetron. Before starting ondansetron, tell your doctor or pharmacist about all other medications you're taking.

Potentially fatal: Apomorphine's hypotensive impact may be exacerbated.

Contraindications

Use with apomorphine (profound hypotension).

Mode of actions

Ondansetron works by inhibiting serotonin at the selective 5-HT3-receptor, both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. Ondansetron's antiemetic function comes from its ability to prevent emesis caused by acute chemotherapy mediated by serotonin.

Dosage & Administration

1. Prevention of nausea-vomiting associated with chemotherapy

1 a. Adult

Parenteral: 32 mg single dose infused over 15 minutes by diluting with 50 ml saline (5% dextrose or 0.9% NaCl) 30 minutes before starting chemotherapy. Alternative therapy: Three dose of 0.15 mg/kg body weight. The first dose is infused over 15 minutes beginning 30 minutes before the starting chemotherapy. Subsequent doses (0.15 mg/kg) are administered 4 and 8 hours after the first dose of administration.

Oral: Highly emetogenic cancer chemotherapy: 24 mg (three 8 mg tablet/oral film) administered 30 minutes before start of emetogenic chemotherapy

Moderate emetogenic cancer chemotherapy: 8 mg (one 8 mg tablet/oral film) administered 30 minutes before start of emetogenic chemotherapy. A further 8 mg dose should be administered after 8 hours of the first dose. One 8 mg tablet/oral film should be administered twice a day (every 12 hours) for 1-2 days after completion of chemotherapy.


1 b. Pediatric

Parenteral (6 months onwards): Three dose of 0.15 mg/kg body weight. The first dose is infused over 15 minutes beginning 30 minutes before starting moderately to highly emetogenic chemotherapy. Subsequent doses (0.15 mg/kg) are administered 4 and 8 hours after the first dose of administration.

Oral (4-11 years): 4 mg tablet/oral film should be taken 30 minutes before the start of chemotherapy. The other 2 doses should be taken 4 and 8 hours after the first dose. Then 4 mg tablet/oral film should be administered 3 times a day (every 8 hours) for 1-2 days after completion of chemotherapy.


2. Prevention of nausea-vomiting associated with radiotherapy

Adults/ Geriatric/ Child of 12 years or over
The recommended dose is 8 mg tablet/oral film 3 times a day.

For total body irradiation: One 8 mg tablet/oral film should be administered 1 to 2 hours before each fraction of radiotherapy administered each day.

For single high-dose fraction radiotherapy to the abdomen: One 8 mg tablet/oral film should be administered 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for 1 to 2 days after completion of radiotherapy.

For daily fractionated radiotherapy to the abdomen: One 8 mg tablet/oral film should be administered 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for each day.


3. Prevention of post-operative nausea-vomiting

3 a. Adults/ Geriatric/ Child of 12 years or over

Parenteral : Undiluted 4 mg intravenously or intramuscularly immediately before induction of anesthesia. The rate of administration should not be less than 30 seconds, preferably over 2 to 5 minutes. Alternatively, the dose can be administered post-operatively if the patient experiences nausea and/or vomiting shortly after surgery

Oral: 16 mg (two 8 mg tablets/oral film) 1 hour before induction of anesthesia.


3 b. Pediatric (1 months to12 years)

Parenteral : Weighing less than 40 kg: 0.1-mg/kg body weight in a Single dose . Weighing more than 40 kg: 4mg single dose The dose should be immediately before induction of anesthesia. The rate of administration should not be less than 30 seconds, preferably over 2 to 5 minutes.

Alternatively, the dose can be administered post-operatively if the patient experiences nausea and/or vomiting shortly after surgery.

4. Nausea-vomiting in gastroenteritis

4 a. Adult: 8 mg three times daily.

4 b. Pediatric (1 month or over): 0.15 mg/kg body weight three times daily.


5. Nausea vomiting in pregnancy
8 mg (1 tablet) 2-3 times daily

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.

Discuss with your doctors and tell them feedback about this medicine.

There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.

Pack Size & Price

50ml bot Price : ৳35

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There are few similar medicines of Emistat are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.