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Napa EXTRA (Tablet)

Manufactured by: Beximco Pharmaceuticals Ltd.

Paracetamol + Caffeine Similar medicine

Napa EXTRA is indicated for Pain,Fever,Headache,Influenza,Migraine,Sore throat,Backache,Toothache,Rheumatic pain,Dysmenorrhea,Colds

Precautions and warnings

Severe hepatic or renal disorder.

Side-effects

Skin rash, diarrhoea, anorexia, GI disturbances, epistaxis (rare).

Drug Interactions

May reduce serum levels w/ anticonvulsants (e.g. phenytoin, barbiturates, carbamazepine). May enhance the anticoagulant effect of warfarin and other coumarins w/ prolonged use. Accelerated absorption w/ metoclopramide and domperidone. May increase serum levels w/ probenecid. May increase serum levels of chloramphenicol. May reduce absorption w/ colestyramine w/in 1 hr of admin. May cause severe hypothermia w/ phenothiazine.

Contraindications

History of hypersensitivity to any of the components.

Mode of actions

Paracetamol exhibits analgesic action by peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat-regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.

Caffeine, a methylxanthine, is a phosphodiesterase inhibitor. It has an antagonistic effect at central adenosine receptors. It is a CNS and resp stimulant. It has bronchodilating and diuretic properties and it facilitates the performance of muscular work.

Dosage & Administration

Adults : 1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily. Not recommended for children below 12 years.

Pregnancy & Lactation

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

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