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Permival (Tablet)

Manufactured by: Opsonin Pharma Limited

Fluphenazine Hydrochloride + Nortriptyline Similar medicine

Permival is indicated for

  • Headache
  • Depression
  • Anxiety
  • Emotional disturbance
  • Tension
  • Fatigue
  • Sleep disorder
  • Bodyache
  • Gastric problems

Precautions and warnings

Patients with glaucoma, prostate enlargement, cardiac failure and myocardial infarction. The drug may impair alertness and abilities to drive a car or operating machinery.

Because of the possibility of cross-sensitivity, fluphenazine hydrochloride should be used cautiously in patients who have developed cholestatic jaundice, dermatoses or other allergic reactions to phenothiazine derivatives.

Psychotic patients on large doses of a phenothiazine drug who are undergoing surgery should be watched carefully for possible hypotensive phenomena. Moreover, it should be remembered that reduced amounts of anesthetics or central nervous system depressants may be necessary.

The effects of atropine may be potentiated in some patients receiving fluphenazine because of added anticholinergic effects.

Side-effects

  • Dryness of mouth
  • drowsiness
  • constipation
  • tachycardia
  • nasal congestion
  • blurred vision
  • excitement.

Drug Interactions

Reduces antihypertensive effects of guanethidine, methyldopa and clonidine. Lithium toxicity. Reduced bioavailability with antacids. Increased risk of arrhythmia when used with drugs that prolong QT interval. May cause electrolyte disturbance when used with diuretics.
Potentially Fatal: Additive CNS depressant effects with alcohol, barbiturates, hypnotics, sedatives, opiates and antihistamines.

Contraindications

Patients with suspected or established subcortical brain damage, in patients receiving large doses of hypnotics, and in comatose or severely depressed states. The presence of blood dyscrasia or liver damage precludes the use of fluphenazine hydrochloride. Fluphenazine hydrochloride is contraindicated in patients who have shown hypersensitivity to fluphenazine; cross sensitivity to phenothiazine derivatives may occur.

Mode of actions

Fluphenazine blocks postsynaptic dopamine D1 and D2 receptors in the mesolimbic system and decreases the release of hypothalamic and hypophyseal hormones. It reduces aggressiveness with disappearance of hallucinations and delusions.

Nortriptyline, a dibenzocycloheptadiene tricyclic antidepressant, is the primary active metabolite of amitriptyline. It increases synaptic concentration of serotonin and/or norepinephrine in the CNS by blocking the neuronal reuptake of norepinephrine and serotonin.

Dosage & Administration

Adult: 1 tablet 2 to 3 times daily.
Child: Not recommended.

Pregnancy & Lactation

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Pack Size & Price

200's pack Price : ৳131.89

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There are some similar medicines of Permival are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.

Are you looking medicine for Headache ?

Aspirin

Indicated for Fever, Headache, Pain/inflammation, Acute coronary syndrome, TIA, MI, Stroke

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Paracetamol + Caffeine

Indicated for Pain, Fever, Headache, Influenza, Migraine, Sore throat, Backache, Toothache, Rheumatic pain, Dysmenorrhea, Colds

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8 more generic are used for Headache

Are you looking medicine for Depression ?

Fluphenazine Hydrochloride + Nortriptyline

Indicated for Headache, Depression, Anxiety, Emotional disturbance, Tension, Fatigue, Sleep disorder, Bodyache, Gastric problems

List of medicines using Fluphenazine Hydrochloride + Nortriptyline
1 more generic are used for Depression

Are you looking medicine for Anxiety ?

Fluphenazine Hydrochloride + Nortriptyline

Indicated for Headache, Depression, Anxiety, Emotional disturbance, Tension, Fatigue, Sleep disorder, Bodyache, Gastric problems

List of medicines using Fluphenazine Hydrochloride + Nortriptyline
1 more generic are used for Anxiety

Are you looking medicine for Emotional disturbance ?

Fluphenazine Hydrochloride + Nortriptyline

Indicated for Headache, Depression, Anxiety, Emotional disturbance, Tension, Fatigue, Sleep disorder, Bodyache, Gastric problems

List of medicines using Fluphenazine Hydrochloride + Nortriptyline
1 more generic are used for Emotional disturbance

Are you looking medicine for Tension ?

Fluphenazine Hydrochloride + Nortriptyline

Indicated for Headache, Depression, Anxiety, Emotional disturbance, Tension, Fatigue, Sleep disorder, Bodyache, Gastric problems

List of medicines using Fluphenazine Hydrochloride + Nortriptyline
1 more generic are used for Tension

Click here to see more indication similarities

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