Precautions and warnings

Patients with glaucoma, prostate enlargement, cardiac failure and myocardial infarction, The drug may impair alertness and abilities to drive a car or operational machinery.


Because of the possibility of grumpy-sensitivity, fluphenazine hydrochloride should be used cautiously in patients who have developed cholestatic jaundice, dermatoses or other allergic reactions to phenothiazine derivatives.


Psychotic Patients on extensive doses of a phenothiazine drug who are undergoing surgery should be watched carefully for workable hypotensive phenomena, Moreover, it should be remembered that reduced amounts of anesthetics or central nervous system depressants may be necessary.


The Effects of atropine may be potentiated in some patients receiving fluphenazine because of added anticholinergic effects.

Drug Interactions

Reduces antihypertensive effects of guanethidine, methyldoxpa and clonidine, Lithium toxicity, Reduced bioavailability with antacids, Increased risk of arrhythmia when used with drugs that draw out QT interval, May cause electrolyte disturbance when used with diuretics.

Potentially Fatal: Additive CNS depressant effects with alcohol, barbiturates, hypnotics, sedatives, opiates and antihistamines.

Contraindications

Patients with suspected or habitual neural structure brain damage, in patients receiving extensive doses of hypnotics, and in comatose or severely depressed states, The presence of blood dyscrasia or liver damage precludes the use of fluphenazine hydrochloride, Fluphenazine hydrochloride is contraindicated in patients who have shown hypersensitivity to fluphenazine; grumpy sensitivity to phenothiazine derivatives may come.

Mode of actions

Fluphenazine blocks postsynaptic dopamine D1 and D2 receptors in the mesolimbic system and decreases the free of neural structure and endocrine gland hormones, It reduces aggressiveness with disappearance of hallucinations and delusions.


Nortriptyline, a dibenzocycloheptadiene tricyclic antidepressant, is the primary active metabolite of amitriptyline, It increases conjugation concentration of serotonin and/or norepinephrine in the CNS by blocking the somatic cell repute of norepinephrine and serotonin.

Dosage & Administration

Adult: 1 tablet 2 to 3 times daily.
Child: Not recommended.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

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