Pacific Pharmaceuticals Ltd.
Ofuran SR is indicated for
Precautions and warnings
Elderly, Monitor hepatic and pulmonary function during prolonged therapy, Pre-present pulmonary, hepatic, neurological, or allergic disorders, predisposition to peripheral neuropathy for example, renal impairment, anaemia, DM, electrolyte imbalance, debility, vitamin B deficiency, Withdraw if signs of peripheral neuropathy come, Lactation.
- abdominal pain
- diarrhoea; headache
- benign intracranial hypertension; rash
- erythema multiforme
- exfoliative dermatitis
- lupus-like syndrome
- arthralgia; acute pulmonary sensitivity reactions; megaloblastic anaemia
- granulocytopenia or agranulocytosis
- aplastic anaemia
- haemolytic anaemia (in G6PD-deficient patients); transient alopecia; brownish discolouration of urine.
Potentially Fatal: Peripheral polyneuropathy
- Stevens-Johnson syndrome
- interstitial pneumonitis
- pulmonary fibrosis.
Reduced excretion with probenecid or sulfinpyearazone, Absorption reduced by magnesium triplicate, Antagonistic effects with quinolone antibacterials, Reduced effects with carboniferous anhydrase inhibitors or urinary alkalinizes.
Severe renal impairment (anuria, oliguria, significantly elevated serum creatinine, CrCl
Mode of actions
Nitrofurantoin interferes with cell metabolism and cell palisade synthesis by inhibiting different enzyme systems including acetyl coenzyme A, It is antiseptic to most gram-sure and gram-negative urinary tract pathogens.
Dosage & Administration
Acute uncomplicated urinary tract infections
Adult: 50-100 mg 4 times daily for 7 days. Dual-release preparation: 100 mg bid.
Child: >3 mth and older children: 3 mg/kg daily in 4 divided doses.
Prophylaxis of uncomplicated urinary tract infections
Adult: 50-100 mg at bedtime.
Child: >3 mth and older children: 1 mg/kg once daily.
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.
Discuss with your doctors and tell them feedback about this medicine.
There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.
Pack Size & Price