Rasilez 300mg (Tablet)
Manufactured by: Novartis Farma SpA, Italy
Aliskiren Similar medicine
Rasilez is indicated for
- Hipertensión
Precautions and warnings
CHF grave, agotamiento de sodio o agotamiento de volumen. Si la diarrea es severa y persistente, deje de tomarla. Lactancia. Los parámetros a monitorear los niveles de potasio en suero y la función renal de forma regular.
Side-effects
- Diarrea
- dispepsia
- ERGE
- dolor abdominal
- hipotensión
- dolor de cabeza
- fatiga
- mareos
- dolor de espalda
- tos
- erupciones
- hiperuricaemia
- gota
- cálculos renales
- hipercalemia
- disminuciones en los niveles de Hb (relacionados con la dosis)
- angioedema y incendios. Potencialmente fatal: reacciones anafilácticas.
Drug Interactions
Junto con otros antihipertensivos, existe un mayor riesgo de hipotensión. Los inhibidores de la ECA, los antagonistas del receptor de angiotensina II y los fármacos antiinflamatorios no esteroideos aumentan el riesgo de insuficiencia renal aguda. Con los AINE, el impacto antihipertensivo puede estar disminuido. La atorvastatina, la itraconazol, el ketoconazol y el verapamilo aumentaron los niveles séricos. Las concentraciones de furosemida y aliskiren cayeron significativamente. Con los diuréticos, los suplementos de potasio o cualquier otro agente que pueda elevar los niveles de potasio en suero, existe un mayor riesgo de hipercalemia.
Con inhibidores de la ECA o antagonistas del receptor de angiotensina II, existe un mayor riesgo de deterioro renal, hipotensión e hipercalemia. Aumento notablemente concentración plasmática con ciclosporina, itraconazol y quinidina.
Contraindications
Historia del angioedema; Se recomienda un deterioro renal significativo en pacientes con diabetes y deterioro renal (TFG), uso concomitante de inhibidores de la ECA o antagonistas del receptor de angiotensina II.
Mode of actions
Aliskiren es un inhibidor de renina directa no péptido, oralmente activo, potente y específico utilizado para tratar HTN. Bloquea la conversión de angiotensinógeno en angiotensina I y, por lo tanto, la síntesis posterior de angiotensina II y aldosterona al bloquear la renina enzima. El tratamiento con aliskiren reduce la actividad de la renina plasmática y las concentraciones de angiotensina I, angiotensina II y aldosterona, a diferencia de los inhibidores de la ECA y los antagonistas del receptor de angiotensina II, que promueven un aumento compensatorio en la actividad de la renina plasmática.
Dosage & Administration
Oral
Hipertensión esencial
Adulto:> 18 años 150 mg una vez al día, aumentó a 300 mg una vez al día si es necesario.
Ancianos: no se necesita ajuste de dosificación.
Deterioro hepático: no se necesita ajuste de dosificación.
Pregnancy & Lactation
Este medicamento no está permitido durante el embarazo. No lo use si está embarazada. Se puede absorber a través de la piel y los pulmones causados pueden dañar los órganos de su hijo no nacido y causar discapacidades congénitas. Control de natalidad estricto efectivo durante el tratamiento y durante seis meses después de detener este medicamento. Si queda embarazada, deje de tomar este medicamento y discuta a su médico de inmediato.
No hay información específica sobre si este medicamento pasa a la leche materna o no. Teniendo en cuenta los posibles riesgos para los niños, no se recomienda la lactancia al usar este medicamento y al menos dos semanas después de la última dosis. Consulte a su médico antes de amamantar.
Pack Size & Price
7's pack Price : ৳437.5
Similar medicine
Manufactured by: Novartis Farma SpA, Italy
Manufactured by: Novartis Farma SpA, Italy
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There are few similar medicines of Rasilez are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
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