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Timex 25mg (Tablet)

Manufactured by: Orion Pharma Ltd.

Clomipramine Hydrochloride Similar medicine

Timex is indicated for

  • Depression
  • Panic disorder
  • Obsessive compulsive disorder
  • Cataplexy
  • Narcolepsy
  • Phobias
  • Premature ejaculation
  • Enuresis
  • Trichotillomania

Precautions and warnings

Cardiovascular insufficiency; narrow down-fish glaucoma; urinary retention; history of epilepsy; renal or hepatic dysfunction; electroconvulsive therapy; hypotension; hyperthyroidism or related treatment with thyroid preparations; dangerous tendencies; surgery; pregnancy and lactation; tasks requiring knowledge alertness; senior; ward of sharp withdrawal.

Side-effects

  • Dryness of mouth; disturbances in micturition; drowsiness
  • increased sweating; sexual dysfunction; confusion
  • paraesthesia
  • ataxia
  • tremors; extrapyramidal symptoms; tinnitus
  • dizziness
  • fatigue
  • headache; wt gain esp in women; gynaecomastia
  • galactorrhoea. Potentially Fatal: Death
  • rare (except in patients with preexisting significant heart block
  • patients on MAOI therapy). Induction of mania in individuals with underlying manic-depressive illness or worsening of psychoses in already psychotic individuals.

Drug Interactions

Barbiturates increase metabolism of tricyclic antidepressants; conversely cimetidine, guanethidine, haloperidol and phenothiazines block the tricyclic metabolism, CNS effects of alcohol increased.

Potentially Fatal: If clomipramine is to be substituted for MAOIs, at least 3 week should pass after discontinuing MAOIs, Risk of hypertension and arrhythmias if co-administered with adrenaline and noradrenaline.

Contraindications

Hypersensitivity, Concomitant use of MAOIs; recovery phase following MI, heart block or other arrhythmias; mania; child.

Mode of actions

Clomipramine is a strong inhibitor of serotonin re-uptake in the brain, Significant antagonism at cholinergic and ?1-receptors, Weak antagonism at dopamine receptors, It has also antidepressant, depressant and anticholinergic effects.

Dosage & Administration

Adult: PO Adjunct in cataplexy associated w/ narcolepsy Initial: 10 mg/day, up to 75 mg/day.
Obsessive-compulsive disorder; Panic disorder; Phobias Initial: 25 mg/day, gradually increase up to 100-150 mg/day if needed. Max: 250 mg/day.
Depression Initial: 10 mg/day, up to 30-150 mg/day if needed. >250 mg/day may be needed in severe cases.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

Pack Size & Price

30's pack Price : ৳150

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There are some similar medicines of Timex are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.

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