Precautions and warnings

Cardiovascular insufficiency; narrow down-fish glaucoma; urinary retention; history of epilepsy; renal or hepatic dysfunction; electroconvulsive therapy; hypotension; hyperthyroidism or related treatment with thyroid preparations; dangerous tendencies; surgery; pregnancy and lactation; tasks requiring knowledge alertness; senior; ward of sharp withdrawal.

Drug Interactions

Barbiturates increase metabolism of tricyclic antidepressants; conversely cimetidine, guanethidine, haloperidol and phenothiazines block the tricyclic metabolism, CNS effects of alcohol increased.

Potentially Fatal: If clomipramine is to be substituted for MAOIs, at least 3 week should pass after discontinuing MAOIs, Risk of hypertension and arrhythmias if co-administered with adrenaline and noradrenaline.

Contraindications

Hypersensitivity, Concomitant use of MAOIs; recovery phase following MI, heart block or other arrhythmias; mania; child.

Mode of actions

Clomipramine is a strong inhibitor of serotonin re-uptake in the brain, Significant antagonism at cholinergic and ?1-receptors, Weak antagonism at dopamine receptors, It has also antidepressant, depressant and anticholinergic effects.

Dosage & Administration

Adult: PO Adjunct in cataplexy associated w/ narcolepsy Initial: 10 mg/day, up to 75 mg/day.
Obsessive-compulsive disorder; Panic disorder; Phobias Initial: 25 mg/day, gradually increase up to 100-150 mg/day if needed. Max: 250 mg/day.
Depression Initial: 10 mg/day, up to 30-150 mg/day if needed. >250 mg/day may be needed in severe cases.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

Pack Size & Price