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Roxadex 5mg/ml (Injection)

Manufactured by: Nuvista Pharma Ltd

Dexamethasone Sodium Phosphate Similar medicine

Roxadex is indicated for

  • Ulcerative colitis
  • Rheumatoid arthritis
  • Multiple sclerosis
  • Nausea
  • vomiting
  • Multiple myeloma
  • Cerebral oedema
  • Shock
  • Inflammatory joint diseases
  • Idiopathic thrombocytopenic purpura
  • Dental surgery
  • Allergic anaphylactic shock
  • Brain tumors
  • Status asthmaticus

Precautions and warnings

Tell your doctor about any infections, kidney disease, liver disease, mental/mood disorders such as psychosis, anxiety, or depression, mineral imbalance such as low potassium/calcium in the blood, thyroid disease, stomach problems, high blood pressure, or heart disease before taking this medication.

Long-term use of corticosteroid drugs can make it harder for your body to respond to physical stress. Tell your doctor or dentist if you are using or have taken this medicine within the last 12 months before undergoing surgery or emergency treatment, or if you acquire a major illness. If you experience unusual exhaustion or weight loss, contact your doctor straight once. Carry a caution card or medical ID bracelet that identifies your usage of this drug if you will be using it for a long time.

This drug has the potential to conceal signs of infection. It may increase your risk of infection or worsen any present infections. Avoid coming into contact with somebody who has an infection that could transmit to others (such as chickenpox, measles, flu). If you think you've been exposed to an infection or want further information, talk to your doctor.

This medication has the potential to induce stomach bleeding. While using this prescription, drinking alcohol on a regular basis may raise your risk of stomach bleeding. Limit your intake of alcoholic beverages. For more information, talk to your doctor or pharmacist.

Before getting any immunizations or vaccinations, inform your doctor that you are taking dexamethasone. Contact with people who have just received live vaccinations should be avoided.


  • Fluid
  • electrolyte disturbances: Sodium retention Fluid retention Congestive heart failure in susceptible patients Potassium loss Hypokalemic alkalosis Hypertension Musculoskeletal: Muscle weakness Steroid myopathy Loss of muscle mass Osteoporosis Pathologic fracture of long bones Vertebral compression fractures Aseptic necrosis of femoral
  • humeral heads Tendon rupture Gastrointestinal: Peptic ulcer with possible subsequent perforation
  • hemorrhage Perforation of the small
  • large bowel
  • particularly in patients with inflammatory bowel disease Pancreatitis Abdominal distention Ulcerative esophagitis Dermatologic: Impaired wound healing Thin fragile skin Petechiae
  • ecchymoses Erythema Increased sweating May suppress reactions to skin tests Burning or tingling
  • especially in the perineal area (after IV injection) Other cutaneous reactions
  • such as allergic dermatitis
  • urticaria
  • angioneurotic edema Neurologic: Convulsions Increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment Vertigo Headache Psychic disturbances Endocrine: Menstrual irregularities Development of cushingoid state Suppression of growth in children Secondary adrenocortical
  • pituitary unresponsiveness
  • particularly in times of stress
  • as in trauma
  • surgery
  • or illness Decreased carbohydrate tolerance Manifestations of latent diabetes mellitus Increased requirements for insulin or oral hypoglycemic agents in diabetics Hirsutism Ophthalmic: Posterior subcapsular cataracts Increased intraocular pressure Glaucoma Exophthalmos Metabolic: Negative nitrogen balance due to protein catabolism Cardiovascular: Myocardial rupture following recent myocardial infarction. Other: Anaphylactoid or hypersensitivity reactions Thromboembolism Weight gain Increased appetite Nausea Malaise Hiccups The following additional adverse reactions are related to parenteral corticosteroid therapy: Rare instances of blindness associated with intralesional therapy around the face
  • head Hyperpigmentation or hypopigmentation Subcutaneous
  • cutaneous atrophy Sterile abscess Post-injection flare (following intra-articular use) Charcot-like arthropathy

Drug Interactions

Aldesleukin, medications that induce bleeding like dabigatran/warfarin, NSAIDs like aspirin/celecoxib/ibuprofen, and mifepristone are some of the items that may interact with this drug.

This medicine has the potential to hasten the elimination of other medications from your body, potentially affecting their effectiveness. Some cancer medications (such as dasatinib, lapatinib, and sunitinib), praziquantel, and rilpivirine, among others, are affected.

If your doctor has prescribed low-dose aspirin (typically 81-162 mg per day) for heart attack or stroke prevention, you should stick to it unless your doctor tells you differently. For more information, consult your doctor.


Avoid this medicine if patients with a known hypersensitivity to the active ingredient to any component of this product, including sulfites

Mode of actions

Dexamethasone is a glucocorticoid that reduces inflammation by preventing leukocyte migration and reversing enhanced capillary permeability. It inhibits the immune system's usual reaction.

Dosage & Administration

Dexamethasone sodium phosphate injection, – For intravenous, intramuscular, intra-articular, intralesional, and soft tissue injection.
Dexamethasone can be given parenterally at doses of 0.5-20 mg daily, either as a single IV/IM injection or by IV infusion.

Child: 200-500 mcg/kg daily.
Cerebral oedema: 10 mg IV initially, then 4 mg IM every 6 hours as required for 2-10 days. Large IV doses should be given slowly to reduce the possibility of cardiovascular collapse.
Shock: By intravenous or intramascular injection or infusion 2-6 mg/kg, repeated if necessary after 2-6 hours. The total daily intake of Dexamethasone, even in acute conditions should not exceed 80 mg except in certain very special circumstances.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

Pack Size & Price

10 amps pack Price : ৳290.2

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There are few similar medicines of Roxadex are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.