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Sentix 0.5mg (Tablet)

Manufactured by: Eskayef Bangladesh Ltd.

Flupenthixol Similar medicine

Sentix is indicated for Depression, Schizophrenia, Psychoses

Precautions and warnings

Patients with convulsive disorders; advanced hepatic, renal, CV or resp disease; tasks requiring mental alertness; elderly (especially with dementia), and debilitated patients; neuroleptics with sedative effect must be withdrawn gradually; history of angle-closure glaucoma; urinary retention; prostatic hyperplasia; breast cancer, prolactin dependent tumours; parkinsonism; myasthenia gravis; pregnancy; Avoid direct sunlight.

Side-effects

Rigidity, tremors, restlessness, tardive dyskinesia, insomnia, dryness of mouth, wt gain, sexual dysfunction, galactorrhoea and menstrual disturbances.

Potentially Fatal: Neuroleptic malignant syndrome (hyperthermia, hypertonicity of skeletal muscles, unconsciousness and autonomic nervous system instability).

Drug Interactions

May potentiate the adverse effects of drugs with antimuscarinic effects e.g. TCAs. Reduced efficacy of levodopa. Increases adverse extrapyramidal symptoms with dopamine antagonists (metoclopramide and prochlorperazine).
Potentially Fatal: Potentiates CNS effects of alcohol, general anaesthetics, hypnotics, anxiolytics and opioids. Blocks antihypertensive effect of guanethidine.

Contraindications

Hypersensitivity. Extremely excitable and overactive patients; mania; porphyria; coma; preexisting CNS depression; bone-marrow supression; phaeochromocytoma. Lactation.

Mode of actions

Flupentixol is a thioxanthene antipsychotic that inhibits dopamine-mediated effects by blocking postsynaptic dopamine receptors in the CNS.

Dosage & Administration

Adult: PO Psychoses Initial: 3-9 mg twice daily. Max: 18 mg/day. Depression Initial: 1 mg/day, increase to 2 mg/day after 1 wk, then to 3 mg/day. Max: 3 mg/day.

IM Psychoses As decanoate: Initial: 20 mg as a test dose. After at least 7 days and depending on response: Subsequent doses of 20-40 mg may be given 2-4 wkly. Usual maintenance: 50 mg 4 wkly to 300 mg 2 wkly, up to 400 mg/wk in severe cases.

Pregnancy & Lactation

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

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