Neostin-R is indicated for
- H. pylori infection
- Benign gastric
- duodenal ulceration
- Acid aspiration during general anesth
- Prophylaxis during NSAID treatment
- Stress ulceration of upper GI
- Zollinger-Ellison syndrome
Precautions and warnings
Exclude malignancy before treating gastric ulcer, Renal and hepatic impairment, Infants, pregnancy and lactation.
- dizziness. Rarely hepatitis
Potentially Fatal: Anaphylaxis
- hypersensitivity reactions.
Delayed absorption and increased peak serum concentration along with propantheline bromide, Ranitidine minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propranolol, May change absorption of pH-dependent drugs (for example, ketoconazole, midazolam, glipizide),May reduce bioavailability along with antacids.
Mode of actions
Ranitidine competitively blocks histamine at H2-receptors of the gastric membrane bone cells which inhibits gastric acid secretion, It does not impact pepsin secretion, pentagastrin-excited intrinsic factor out secretion or serum gastrin.
Dosage & Administration
Adult: PO Benign gastric and duodenal ulceration Initial: 300 mg at bedtime or 150 mg twice daily for 4-8 wk depending on the condition.
For prevention of NSAID-associated ulceration: 150 mg bid.
Eradication of H. pylori infection 300 mg once daily or 150 mg twice daily w/ amoxicillin and metronidazole for 2 wk. May continue w/ ranitidine for a further 2 wk.
GERD 150 mg twice daily or 300 mg at bedtime for up to 8 wk. Severe: 150 mg 4 times/day for 12 wk. Pathological hypersecretory conditions Initial: 150 mg 2-3 times/day, up to 6 g/day if needed.
Acid aspiration during general anesth 150 mg 2 hr before induction of anesth and preferably, an additional dose on the previous evening.
Chronic episodic dyspepsia 150 mg twice daily for up to 6 wk.
Short-term symptomatic dyspepsia 75 mg, up to 4 doses/day if needed. Max: 2 wk of continuous use at each time.
Prophylaxis during NSAID treatment 150 mg twice daily.
IV Pathological hypersecretory conditions Initial: 1 mg/kg/hr, may increase slowly after 4 hr if needed. Stress ulceration of upper GI tract Priming dose: 50 mg via inj, then 125-250 mcg/kg/hr via infusion, then transfer to PO 150 mg twice daily once oral feeding is resumed.
IV/IM Acid aspiration during general anesth 50 mg 45-60 mins before the induction of anasth.
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.
Discuss with your doctors and tell them feedback about this medicine.
There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.
Pack Size & Price