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Zoleta 2.5 mg (Tablet)

Manufactured by: Nuvista Pharma Ltd

Letrozole Similar medicine

Zoleta is indicated for

  • Breast cancer

Precautions and warnings

Severe renal impairment; severe hepatic impairment; osteoporosis, Caution when energetic or in operation machinery.

Side-effects

  • Hot flushes
  • arthralgia
  • nausea
  • vomiting
  • fatigue
  • dizziness
  • headache
  • dyspepsia
  • constipation
  • diarrhoea
  • anorexia
  • alopoecia
  • increased sweating
  • rash
  • peripheral oedema
  • osteoporosis
  • musculoskeletal pain
  • vaginal irritation. Potentially Fatal: Thromboembolic events.

Drug Interactions

Plasma levels reduced by tamoxifen.

Contraindications

Premenopausal women and children; hypersensitivity.

Mode of actions

Letrozole competitively binds to the heme group of aromatase, a cytochrome P450 enzyme which catalyzes conversion of androgen to estrogen, up to inhibition of the enzyme and a key reduction in plasma estrogen levels.

Dosage & Administration

Adult: PO Adjuvant therapy for post menopausal women with hormone receptor positive early breast cancer; Advanced breast cancer in postmenopausal women 2.5 mg once daily.

Hepatic impairment: Reduce dose by 50% in patients with cirrhosis and severe hepatic impairment; recommended dose: 2.5 mg on alternate days.

Pregnancy & Lactation

This medicine must not be used during pregnancy. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict two effective types of birth control starting one month before and during treatment and for three years after stopping this medicine. Discuss with your doctors if you are not sure which types of birth control are effective for you. You must need to take pregnancy tests regularly during your treatment with this medicine and for at least three years after taking this medicine. If it seems that you do become pregnant stop taking this medicine and call your doctor immediately. If you really become pregnant, miss a menstrual period, or have sex without using two forms of birth control. In some cases, your doctor can prescribe emergency contraception to prevent pregnancy. People on this medicine should not donate blood during the treatment and for three years afterward.

This medicine is also contraindicated breast milk. Breastfeeding is not recommended while using this medication and for three years afterward.

Pack Size & Price

5's pack Price : ৳200.6

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