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Rabix-VC 2.5 IU/ml (Injection)

Manufactured by: Incepta Pharmaceuticals Ltd.

Rabies Vaccine (Human) BP Similar medicine

Rabix-VC is indicated for

  • To prevent Rabies virus

Precautions and warnings

Possibility of immune convoluted reaction 2-21 days after booster doses of HDCV (Human diploid cell cultures rabies vaccine); symptoms include arthralgia, arthritis, nausea, malaise, angioedema, fever and vomiting, Caution when used in patients with bleeding disorders, patients on anticoagulant treatment, severely immunocompromised patients, Not to be used in patients with habitual diagnosis of rabies, Post exposure prophylaxis may be started careless of the length of clock from possible exposure, as abundant as objective signs of rabies infection are not present, Pregnancy, lactation.

Side-effects

  • Minor local reactions like pain
  • erythema
  • oedema
  • pruritus
  • induration at the injection site
  • lasting to 24-48 hours. Moderate fever
  • shivering
  • fainting
  • asthenia
  • dizziness
  • respiratory manifestations (dyspnoea
  • wheezing)
  • fever
  • abdominal pain
  • vomiting
  • allergic skin reactions (urticaria
  • rash
  • itching).

Drug Interactions

Concurrent use with immunosuppressants may reduce the efficacy of vaccines.

Contraindications

Pre-exposure
Severe fever, febrile infection, acute disease, progressive chronic diseases.

Known Hypersensitivity reactions to rabies vaccine or any of its components, Post-exposure
No contraindication to post-exposure treatment, because rabies is fatal disease, any contraindication to exposure, treatment should be thoughtful carefully before disqualifying an individual for opposing-rabies treatment.


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Mode of actions

Rabies vaccine is an inactivated virus vaccine that is used for active immunization against rabies, It can be used for pre- and post-exposure immunization, For post-exposure immunization, it is often used in conjunction with rabies immunoglobulins as it takes about 7-10 days for the special antibodies to develop.

Dosage & Administration

Adult: 1 ml for children and adults:

a) Pre-exposure immunization Primary-vaccination: According to the WHO recommendations 1 injection by the intramuscular route on days D0, D7, D21 or D28, followed by a booster dose one year later. Boosters Thereafter, one injection every 5 years or when the titre is found to be less than 0.5 I.U./ml.

b) Post-exposure treatment Intramuscular schedule:
Non-vaccinated individuals: Treatment consists of 5 injections. Intramuscular injections to be given on Day 0, D3, D7, D14 and D28 subsequent to contact with an animal confirmed or suspected of being rabid. In case of severe (WHO category 3) wounds, immunoglobulin should be administered as soon as possible.

Fully vaccinated individuals: If vaccine administered in less than 5 years of exposure (cell culture rabies vaccine): 2 injections on D0, D3. If vaccine administered in more than 5 years of exposure or incomplete vaccination: 5 injections on D0, D3, D7, D14 and D28 with administration of immunoglobulin if required. Post exposure vaccination must be administered on the basis of severity under medical supervision.

Intradermal schedules: One intradermal (ID) dose is comprised of 0.1 ml.
WHO Modified Thai Red Cross (2-2-2-0-2) schedule: Day 0: 2 injections each of 0.1 ml at separate sites, Day 3: 2 injections each of 0.1 ml at separate sites, Day 7: 2 injections each of 0.1 ml at separate sites, Day 28: 2 injections each of 0.1 ml at separate sites.

To reconstitute the vaccine, transfer content of supplied diluent into the vial containing freeze-dried preparation. Do not shake. After reconstitution the solution should be homogeneous, clear and free from any particles. Vaccine must be injected immediately after reconstitution and the syringe should be destroyed after use.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

Pack Size & Price

1's Price : ৳500

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There are some similar medicines of Rabix-VC are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.

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