Precautions and warnings

Neuromuscular issues, hearing loss, and severe skin damage are all possibilities. Avoid using huge amounts of the product or using it for an extended period of time. If the tympanic membrane is perforated, do not use Lactation and pregnancy. Insufficiency of the liver and kidneys.

Drug Interactions

When used with other nephrotoxic medicines, bacitracin zinc increases the risk of nephrotoxicity. It's possible that it boosts the effects of neuromuscular blockers.

Other aminoglycosides (for example, paromomycin), bacitracin, cisplatin, vancomycin, amphotericin B, polymyxin B, colistin, and viomycin have additive nephrotoxic and neurotoxic effects. Increased toxicity in combination with diuretics (for example, ethacrynic acid, furosemide). Other medications' absorption may be hampered (for example, phenoxymethylpenicillin, digoxin, methotrexate and some vitamin). It's possible that OCs' efficacy will be reduced. Acarbose's impact may be enhanced. Non-depolarizing muscle relaxants may be enhanced by this compound. It's possible that it'll counteract the parasympathomimetic effects of neostigmine and pyridostigmine. In patients using bisphosphonates, it may raise the risk of hypocalcemia. When taken with anticoagulants, it may cause an increase in INR. Oral typhoid vaccination may be rendered ineffective.

Contraindications

Aminoglycoside hypersensitivity and Nerve deafness that has been there for a long time for Infants and neonates.

Mode of actions

Neomycin binds to the 30S subunits of the bacterial ribosome, limiting protein synthesis and hence affecting DNA synthesis. It has an antibacterial spectrum similar to gentamicin. It's effective against a wide range of gram-negative bacteria, as well as some staphylococci strains. Bacitracin, on the other hand, inhibits bacterial cell wall formation and is effective against a wide range of gram-positive and gram-negative bacteria (including staphylococci, streptococci, corynebacteria, and clostridia) (for example, Neisseria and Haemophilus influenzae). They're frequently encountered in topical formulations as broad-spectrum antibacterial agents in combination.

Dosage & Administration

Adult: Topical: Cream: Apply 3 times/day.
Powder: Apply 2-4 times/day.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Another study shows that this medicine is not allowed during pregnancy. Do not use it if you are pregnant. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict effective birth control during treatment and for six months after stopping this medicine. If you do become pregnant, stop taking this medicine and discuss your doctor right away.

There is no specific information on whether this medicine passes into breast milk or not. Considering the possible risks for the children, breastfeeding while using this medicine is not recommended and at least two weeks after the last dose. Consult your doctor before breastfeeding.

Pack Size & Price