Precautions and warnings

Before using this drug, talk to your doctor about your medical history, especially if you have severe renal disease, are pregnant, or are a mother who feeds her newborn breast milk.

Drug Interactions

Strong-acting diuretics (such as furosemide) and aminoglycosides are likely to be more nephrotoxic when taken with this medication. It may also help oral anticoagulants work better.

It's possible that OCs' efficacy will be reduced. Cefuroxime excretion is prolonged by probenecid, resulting in a higher peak serum level.

Contraindications

Hypersensitivity to the active ingredient to cephalosporins.

Mode of actions

Cefuroxime binds to one or more penicillin-binding proteins (PBPs), which inhibits the last transpeptidation stage of peptidoglycan formation in bacterial cell walls, halting biosynthesis and causing bacterial cell death.

Clavulanic acid has a high affinity for and binds to specific lactamases that inactivate Cefuroxime by hydrolyzing its lactam ring, in addition to inhibiting beta-lactamase-producing bacteria. When Cefuroxime is combined with clavulanate potassium, the antibacterial spectrum of Cefuroxime is expanded to encompass numerous bacteria that are resistant to Cefuroxime and other penicillins and cephalosporins.

Dosage & Administration

Adolescents & adults:
Pharyngitis or Tonsillitis: 250 mg twice daily 5-10 days
Acute bacterial maxillary sinusitis: 250 mg twice daily 10 days
Acute bacterial exacerbation of chronic bronchitis: 250-500 mg twice daily 10 days
Secondary bacterial infections of acute bronchitis: 250-500 mg twice daily 5-10 days
Community acquired pneumonia: 250-500 mg twice daily 5-10 days
Uncomplicated skin & skin-structure infections: 250-500 mg twice daily 10 days
MDR Typhoid fever: 500 mg twice daily 10-14 days
Uncomplicated urinary tract infection: 250 mg twice daily 7-10 days
Uncomplicated gonorrhea: 1000 mg single dose
Lyme disease: 500 mg twice daily 20 days

Paediatric patients (3 months to 12 years)
Pharyngitis or Tonsillitis: 20 mg/kg/day in two divided doses 5-10 days
Acute otitis media: 30 mg/kg/day in two divided doses 10 days
Acute bacterial maxillary sinusitis: 30 mg/kg/day in two divided doses 10 days
Community acquired pneumonia: 30 mg/kg/day in two divided doses 5-10 days
MDR Typhoid fever: 30 mg/kg/day in two divided doses 10-14 days
Uncomplicated skin & skin-structure infections: 30 mg/kg/day in two divided doses 10 days
Uncomplicated urinary tract infection: 20 mg/kg/day in two divided doses 7-10 days

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.

Discuss with your doctors and tell them feedback about this medicine.

There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.

Pack Size & Price