Precautions and warnings

Severe renal impairment; pregnancy, lactation; hypersensitivity to penicillins.

Drug Interactions

May raise the toxic effect of tough-impermanent diuretics (for example, furosemide) and ahminoglycosides, May raise the effect of oral anticoagulants, May reduce the efficacy of Cos, Probenecid prolongs the excretion of cefuroxime and elevated peak serum even.

Contraindications

Hypersensitivity to cephalosporins.

Mode of actions

Cefuroxime binds to one or more of the penicillin-tight proteins (PBPs) which inhibits the last transpeptidation step out of peptidoglycan synthesis in bacterial cell fence, thus inhibiting biosynthesis and stunning cell wall assembly resulting in bacterial cell death.


Addition of clavulanate inhibits important-lactamase-producing bacteria; Clavulanic acid has a high affinity for and binds to certain ?-lactamases That generally inactivate Cefuroxime by hydrolyzing its lactic Call, Combining clavulanate potassium with Cefuroxime extends the antibacterial spectrum of Cefuroxime to include many bacteria normally resistant to Cefuroxime and other penicillins and cephalosporins.

Dosage & Administration

Adolescents & adults:
Pharyngitis or Tonsillitis: 250 mg twice daily 5-10 days
Acute bacterial maxillary sinusitis: 250 mg twice daily 10 days
Acute bacterial exacerbation of chronic bronchitis: 250-500 mg twice daily 10 days
Secondary bacterial infections of acute bronchitis: 250-500 mg twice daily 5-10 days
Community acquired pneumonia: 250-500 mg twice daily 5-10 days
Uncomplicated skin & skin-structure infections: 250-500 mg twice daily 10 days
MDR Typhoid fever: 500 mg twice daily 10-14 days
Uncomplicated urinary tract infection: 250 mg twice daily 7-10 days
Uncomplicated gonorrhea: 1000 mg single dose
Lyme disease: 500 mg twice daily 20 days

Paediatric patients (3 months to 12 years)
Pharyngitis or Tonsillitis: 20 mg/kg/day in two divided doses 5-10 days
Acute otitis media: 30 mg/kg/day in two divided doses 10 days
Acute bacterial maxillary sinusitis: 30 mg/kg/day in two divided doses 10 days
Community acquired pneumonia: 30 mg/kg/day in two divided doses 5-10 days
MDR Typhoid fever: 30 mg/kg/day in two divided doses 10-14 days
Uncomplicated skin & skin-structure infections: 30 mg/kg/day in two divided doses 10 days
Uncomplicated urinary tract infection: 20 mg/kg/day in two divided doses 7-10 days

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.

Discuss with your doctors and tell them feedback about this medicine.

There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.

Pack Size & Price