Precautions and warnings

Tell your doctor about your medical history, especially if you have a personal or family history of bipolar illness, mania, or seizure disorders, work that requires mental alertness, or renal or hepatic impairment before taking this medicine.

This medication may cause dizziness or drowsiness. You may become dizzy or sleepy if you consume alcohol or cannabis. Do not drive, operate machinery, or engage in any other activity that requires attentiveness until you are sure you can do so safely. Alcoholic beverages should be avoided. If you use cannabis, talk to your doctor.

Drug Interactions

Other medicines that can cause bleeding, such as antiplatelet drugs, clopidogrel, and NSAIDs, may interact with this medication.

When used with this drug, aspirin can increase the risk of bleeding. If your doctor has prescribed low-dose aspirin (typically 81-162 mg per day) for heart attack or stroke prevention, you should stick to it unless your doctor tells you differently. For more information, consult your doctor or pharmacist.

Taking this medication with MAO inhibitors could result in a dangerous drug interaction. During treatment with this medication, do not take MAO inhibitors such as isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, or tranylcypromine. For two weeks before and after treatment with this medicine, most MAO inhibitors should be avoided. When should you start or stop taking this medication? Consult your doctor.

Tell your doctor if you're using any other drowsy medications, such as alcohol, cannabis, antihistamines like cetirizine, diphenhydramine, sleep or anxiety medications like alprazolam, diazepam, zolpidem, muscle relaxants, or opioid pain relievers like codeine.

Concurrent administration with MAOIs has the potential to cause significant or deadly responses; therefore, it should not be begun until at least 2 weeks after quitting escitalopram or vice versa. Moclobemide has been linked to an increased risk of serotonin syndrome.

Contraindications

Concomitant use with or within 2 wk of MAOI withdrawal.

Mode of actions

Escitalopram reduces serotonin (5-HT) reuptake in CNS neurons and potentiates serotonergic activity. It has only a minor impact on norepinephrine and dopamine neuronal reuptake.

Dosage & Administration

Adult: PO Depression; Anxiety; Obsessive compulsive disorder 10 mg once daily. Max: 20 mg/day.
Panic disorder Initial: 5 mg/day, up to 10 mg/day after 7 days if needed. Max: 20 mg/day.

Elderly: Half the adult dose.
Hepatic impairment: Dosage adjustments may be required.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

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