Acme Laboratories Ltd.
Elodep is indicated for
Major depressive disorder
- Panic disorder
- Obsessive compulsive disorder
- Anxiety disorder
Precautions and warnings
History of mania or seizure disorders; work requiring mental alertness; renal and hepatic impairment; pregnancy, lactation; withdraw gradually. Children and adolescents
- increased sweating
- ejaculation disorder
- somnolence; postural hypotension
- taste disturbances. Increased appetite
- wt gain.
Increased risk of bleeding when used with aspirin, NSAIDs or drugs that affect coagulation. Serum levels may be reduced by CYP2C19 inducers (e.g. carbamazepine, rifampin, phenytoin) or CYP3A4 inducers (e.g. nafcillin, nevirapine). Serum levels may also be increased by CYP2C19 inhibitors (e.g. fluconazole, fluvoxamine, omeprazole) or CYP3A4 inhibitors (e.g. azole antifungals, clarithromycin). May increase serum levels of desipramine or metoprolol. Increased risk of serotonin syndrome when used with linezolid or sibutramine. Escitalopram may enhance the sedative effects of alcohol.
Potentially Fatal: Concomitant administration with MAOIs may lead to serious or fatal reactions; should not be started until at least 2 wk after stopping escitalopram or vice versa. Moclobemide may increase the risk of serotonin syndrome.
Concomitant use with or within 2 wk of MAOI withdrawal.
Mode of actions
Escitalopram selectively inhibits CNS neuronal re-uptake of serotonin (5-HT) and potentiates serotonergic activity. It has minimal effects on norepinephrine and dopamine neuronal re-uptake.
Dosage & Administration
Adult: PO Depression; Anxiety; Obsessive compulsive disorder 10 mg once daily. Max: 20 mg/day.
Panic disorder Initial: 5 mg/day, up to 10 mg/day after 7 days if needed. Max: 20 mg/day.
Elderly: Half the adult dose.
Hepatic impairment: Dosage adjustments may be required.
Pregnancy & Lactation
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Pack Size & Price