Precautions and warnings

Pregnancy and breastfeeding. A history of alcohol or drug abuse. High blood pressure and other heart or circulation problems that could get worse if your blood pressure or heart rate increases. Existing psychosis or bipolar disorder—watch for signs of aggression or hostility. A history of seizures. Use in children.

Drug Interactions

This drug may make blood pressure medicines less effective. Its levels in the blood can go down if taken with carbamazepine. Its effects can be stronger if taken with certain drugs that block the CYP2D6 enzyme, such as chlorpromazine, delavirdine, fluoxetine, miconazole, paroxetine, pergolide, quinidine, quinine, ritonavir, and ropinirole. It can increase the amount of phenytoin and tricyclic antidepressants (TCAs) in the blood. Taking it with sibutramine may cause serious high blood pressure and a fast heartbeat. Mixing it with alcohol may cause drowsiness.

Dangerous Effects: Taking this drug with clonidine can cause severe toxic reactions. Using it with MAOIs may lead to a very high risk of dangerously high blood pressure.

Contraindications

High levels of anxiety, tension, or restlessness; glaucoma; Tourette's syndrome or tics. Known serious heart issues like severe structural heart problems, heart muscle disease, dangerous heart rhythms, or other major heart disorders that could raise the risk of sudden death. For the extended-release form: severe high blood pressure, heart failure, irregular heartbeat, overactive thyroid, or a recent heart attack or chest pain (angina).

Mode of actions

Methylphenidate is a medicine that stimulates the brain and affects the nervous system by increasing certain natural chemicals.

Dosage & Administration

Adult: PO Narcolepsy 20-30 mg/day in divided doses. Effective range: 10-60 mg/day.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

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