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Xalcort 6mg (Tablet)

Manufactured by: Beacon Pharmaceuticals Ltd.

Deflazacort Similar medicine

Xalcort is indicated for Allergic and inflammatory disorders

Precautions and warnings

Adrenal suppression and infection, child, adolescents, elderly, history of TB and steroid myopathy, hypertension, recent MI, CHF, liver failure, renal impairment, DM and glaucoma (including family history), osteoporosis, corneal perforation, severe affective disorders, epilepsy, peptic ulcer, hypothyroidism, pregnancy and lactation.

Side-effects

GI disturbances, musculoskeletal, endocrine, neuropsychiatric, ophthalmic, fluid and electrolyte disturbances; susceptible to infection, impaired healing, hypersensitivity, skin atrophy, striae, telangiectasia, acne, myocardial rupture following recent MI, thromboembolism.

Drug Interactions

Antacids, ACE inhibitors, acetazolamide, adrenergic neuron blockers, antidiabetics, aspirin, barbiturate, ?-blockers, calcium-channel blockers, carbamazepine, carbenoxolone, cardiac glycosides, clonidine, coumarins, diazoxide, diuretics, erythromycin, hydralazine, ketoconazole, methotrexate, methyldopa, mifepristone, minoxidil, moxonidine, nitrates, nitroprusside, NSAIDs, oestrogens, phenytoin, primidone, rifamycins, ritonavir, somatropin, ?2 sympathomimetics, theophylline, vaccines.

Contraindications

Systemic infection; live virus vaccines in those receiving immunosuppressive doses.

Mode of actions

Deflazacort, derived from prednisolone, is a corticosteroid with mainly glucocorticoid activity. An anti-inflammatory dose of 6 mg deflazacort is equiv to 5 mg prednisolone.

Dosage & Administration

Oral
Allergic and inflammatory disorders
Adult: Initially, up to 120 mg daily. Maintenance: 3-18 mg/day.

Child: 0.25-1.5 mg/kg/day given on alternate days.
Hepatic impairment: Dose reductions may be needed.

Pregnancy & Lactation

FDA has not yet classified the drug into a specified pregnancy category.