Precautions and warnings

Avoid sharp withdrawal as it may hurried thyroid force or aggravate hyperthyroidism, Liver injury; vascular disease, renal failures, suspected pheochromocytoma and prinzmetal's variable angina; worsening cardiac failure or fluid retention during increase in dosage of carvedilol; diabetic patients, Pregnancy.

Drug Interactions

Decreased serum levels along with rifampicin, Combination along with Ca carry blockers (for example, verapamil and diltiazem) can head to bradycardia and myocardial depression, Potentiates insulin-induced hypoglycemic process, May increase hypoglycemic effects of anti diabetic agents, Increased risk of bradycardia along with digoxin, Increased risk of hypotension and bradycardia along with reserpine, MAOIs, clonidine, May increase cyclosporin concentrations, Concurrent use along with ether, cyclopropane, trichloroethylene may increase the risk of hypotension and heart failure.

Contraindications

Hypersensitivity; severe chronic heart failure, bronchial asthma or related bronchospastic conditions; severe hepatic impairment, Patients with NYHA sort IV cardiac failure, 2nd or 3rd ° AV block, disturbed sinus syndrome (unless a abiding pacemaker is in identify), cariogenic shock or severe bradycardia,Lactation.

Mode of actions

Carvedilol is a non discriminating ?-endocrine Blocking agent which causes vasodilation by blocking the activity important-1 receptors, It exerts antihypertensive effect partly by reducing total peripheral resistance and vasodilation.

Dosage & Administration

Hypertension
Adult: Initially, 12.5 mg once daily increased to 25 mg once daily after 2 days. Alternatively, initial dose of 6.25 mg bid increased to 12.5 mg bid after 1-2 wk, increased further if necessary to 50 mg once daily or in divided doses.
Elderly: 12.5 mg once daily.
Angina pectoris
Adult: Initially, 12.5 mg bid increased to 25 mg bid after 2 days.
Heart failure
Adult: Initially, 3.125 mg bid, doubled to 6.25 mg bid after 2 wk if tolerated, then gradually increased to the max dose the patient can tolerate at intervals of not 85 kg: 50 mg bid;

Pregnancy & Lactation

This medicine is not allowed during pregnancy. Do not use it if you are pregnant. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict effective birth control during treatment and for six months after stopping this medicine. If you do become pregnant, stop taking this medicine and discuss your doctor right away.

There is no specific information on whether this medicine passes into breast milk or not. Considering the possible risks for the children, breastfeeding while using this medicine is not recommended and at least two weeks after the last dose. Consult your doctor before breastfeeding.

Pack Size & Price