Precautions and warnings

If previously the patient has been proofed with tranquilizers with depressant effect these should be indrawn gradually.

Drug Interactions

May potentiate the inauspicious effects of drugs with antimuscarinic effects for example, TCAs, Reduced efficacy of levodopa, Increases harmful extrapyearamidal symptoms with dopamine antagonists (metoclopramide and prochlorperazine),Potentially Fatal: Potentiates CNS effects of alcohol, general anesthetics, hypnotics, anxiolytics and opioids, Blocks antihypertensive effect of guanethidine.

Additive toxicity with antimuscarinics, CNS depressants, Response to TCA may be fast with thyroid hormones; pressure effects of sympathomimetics may be increased; risk of serotonin syndrome when condemned with other antidepressants.

Antidiabetic Dosage may need to be keyed.

Contraindications

The immediate recovery phase after myocardial infarction, Defects in culm-ramify conduction, Untreated consorting fish glaucoma, Acute alcohol, barbiturate and opiate intoxications, Flupentixol-Melitracen should not be granted to patients who have standard a MAO-inhibitor within two weeks, Not recommended for nervous or overactive patients since its actuating effect may head to exaggeration of these characteristics.

Mode of actions

Flupentixol is a thioxanthene antipsychotic that inhibits dopamine-mediate effects by blocking postsynaptic dopamine receptors in the CNS.

Melitracen is a TCA with psychological state properties.

Dosage & Administration

Adults: Usually 2 tablets daily; morning and noon. In severe cases the morning dose may be increased to 2 tablets.
Elderly: 1 tablet in the morning.
Maintenance dose: Usually 1 tablet in the morning. In cases of insomnia or severe restlessness additional treatment with a sedative in the acute phase is recommended.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

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