Precautions and warnings

Inform your doctor about your medical history, particularly if you have had an irregular heartbeat, angina, a previous heart attack, high blood pressure, or a seizure.

This medication has the potential to make you dizzy. You may become dizzy if you consume alcohol or use cannabis. Do not drive, operate machinery, or engage in any other activity that requires attentiveness until you are sure you can do so safely. Limit your intake of alcoholic beverages. If you use cannabis, talk to your doctor.

Drug Interactions

Salbutamol and levalbuterol are quite similar. When taking Salbutamol, avoid taking any drugs that include levalbuterol.

Contraindications

Patients having a history of allergy to any of the ingredients in the salbuatmol inhaler should not use it. Although intravenous Salbutamol and occasionally Salbutamol pills are used to treat premature labor that isn't accompanied by problems like placenta praevia, ante-partum haemorrhage, or maternal toxemia, Salbutamol inhaler preparations aren't. During the first or second trimesters of pregnancy, salbutamol preparation should not be used for threatening abortion.

Mode of actions

Salbutamol is a bronchodilator that is a direct-acting sympathomimetic with beta-adrenergic activity and selective action on receptors. It also makes the uterus less contractile.

Dosage & Administration

Adult: PO Acute bronchospasm 2-4 mg (up to 8 mg) 3-4 times/day. Extended release 8 mg twice daily.

Children
2 - 6 years: 2.5 ml syrup, 3-4 times daily
6-12 years: 5 ml syrup, 3-4 times daily
Over 12 years: 5-10 ml syrup, 3-4 times daily (2-4 mg tablet, 3-4 times daily)

Inhalation Capsule: Adults:
For the relief of acute asthma or before exercise 400 µg (2 ConviCaps). The recommended dose for maintenance treatment or prophylactic therapy is 400 µg (2 ConviCaps) three to four times a day. Maximum dose is 1600 µg/day.

Children:
In the treatment of episodic asthma or before exercise 200 µg (1 ConviCap). The recommended dose for maintenance treatment or prophylactic treatment is 200 µg (1 ConviCap) three to four times a day. Maximum dose is 800 µg/day.

As aerosol: Inhalation Acute bronchospasm 100 or 200 mcg 3-4 times/day. 2 puffs may be given prior to exertion to prevent exercise-induced bronchospasm.

Acute severe asthma As MDI: 4-6 inhalations every 10-20 mins. Severe bronchospasm Via nebuliser: 2.5-5 mg up to 4 times/day.

Children For relief of acute bronchospasm in the maintenance of episodic asthma or before exercise: one 1 puff may be administered as a single dose.

For routine maintenance and prophylaxis therapy: one 1 puff three or four times daily, increasing if necessary to two puffs three or four times daily.
Elderly The dosage is the same as that for adults.

Nebuliser Solution
Nebuliser Solution is for inhalation use only, to be breathed in through the mouth, under the direction of a physician, using a suitable nebuliser. The solution should not be injected or swallowed.
Adults (including the elderly): 2.5 mg to 5 mg salbutamol up to four times a day. Up to 40 mg per day can be given under strict medical supervision in hospital.

Children 4 years and above: 2.5 mg to 5 mg up to four times a day.
Children 18 months to 4 years: 2.5 mg up to four times a day.The dose may be increased to 5 mg if necessary.
Infants under 18 months old: 1.25 mg (0.25 mg/kg) to 2.5 mg up to four times a day.

Respirator Solution
By Intermittent Administration : Adult : Respirator Solution 0.5-1.0 ml should be diluted to final volume of 2.0-4.0 ml with normal saline for injection. The resulting solution is inhaled from a suitably driven nebulizer until aerosol generation ceases. Should take about 10 minutes.
Respirator Solution may be used undiluted for intermittent administration. For this 2.0 ml of the solution is placed in the nebulizer and the patient allowed to inhale until bronchodilatation is achieved. This usually takes 3-5 minutes.

Children under 12 years age: 0.5 ml of the solution diluted to 2.0-4.0 ml with normal saline. Intermittent treatment may be repeated four times a day.

By Continuous Administration : Respirator Solution is diluted with normal saline for injection, 1-2 ml solution made upto 100 ml with diluent. The diluted solution is administered as an aerosol by a suitably driven nebulizer. The usual rate of administration is 1-2 mg/hour.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

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