Cloradex (E/E Drops)
Manufactured by: Navana Pharmaceuticals Ltd.
Chloramphenicol 0.5% + Dexamethasone 0.1% Eye/Ear drop Similar medicine
Cloradex is indicated for
- Allergic conjunctivitis
- Acute purulent conjunctivitis
- Corneal ulceration
- Keratitis disciformis
- Post-herpetic keratitis
- Allergic blepharitis
- Acute
- chronic iritis
- Iridocyclitis
- Otitis externa
- infective
- inflammatory ear infections.
Precautions and warnings
Do not use for long periods of time. Stop using it right away if you have any allergic reactions on your skin.
Side-effects
- Ophthalmic application: Hypersensitivity reactions including rashes
- fever
- angioedema. Ear drops: Ototoxicity.
Drug Interactions
Iron and vitamin B12 may not work as well in patients with anemia. The medicines phenobarbitone and rifampin can make chloramphenicol less effective. This drug can also reduce the effectiveness of oral contraceptives (birth control pills).
Warning: This drug can increase the effects of blood thinners, diabetes medicines taken by mouth, and phenytoin (a seizure medication), which can be dangerous. Do not use it together with other medicines that weaken bone marrow function.
Contraindications
Do not use this medication if you have had an allergic or toxic reaction to it before. Avoid use if you have a perforated (torn) eardrum, herpes simplex or other viral infections of the eye or ear, or fungal infections (mycosis).
Mode of actions
Dexamethasone is an artificial steroid that reduces inflammation by stopping white blood cells from moving to the affected area and by making blood vessels less leaky. It also weakens the normal immune response.
Chloramphenicol works by blocking bacteria from making proteins. It does this by attaching to the 50s part of the bacterial ribosome, which stops the bacteria from forming the bonds they need to build proteins. Chloramphenicol can either stop bacteria from growing or kill them, and it works against bacteria like H. influenzae, N. meningitidis, and S. pneumoniae.
Dosage & Administration
Ocular infections Adult: Instill 1 drop of asolution every 2 hr. Increase dosage interval upon improvement. To continue treatment for at least 48 hr after complete healing.
Otic/Aural Otitis externa Adult: Instill 2-3 drops into the ear bid-tid.
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.
Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.
This medicine passes into breast milk. Talk to your doctor before breastfeeding.
Pack Size & Price
5ml drop Price : ৳70
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