Precautions and warnings

Gout Flare: When starting medications that lower uric acid, like Febuxostat, it’s common to have more gout flare-ups at first. If you get a gout flare during treatment, you do not need to stop taking Febuxostat. Taking preventive medicine, such as a non-steroidal anti-inflammatory drug (NSAID) or colchicine when you begin treatment, can help reduce flare-ups for up to six months.

Drug Interactions

It may raise the amount of mercaptopurine and azathioprine in the blood. It can also change how xanthine oxidase substrate drugs, like theophylline, are broken down in the body.

Contraindications

People who are taking azathioprine, mercaptopurine, or theophylline as part of their treatment.

Mode of actions

Febuxostat works by blocking xanthine oxidase, the enzyme responsible for turning hypoxanthine into xanthine and then into uric acid. By stopping this process, febuxostat lowers the amount of uric acid in the blood.

Dosage & Administration

For treatment of hyperuricemia in patients with gout, Febuxostat is recommended at 40 mg or 80 mg once daily.

The recommended starting dose of Febuxostat is 40 mg once daily. For patients who do not achieve a serum uric acid (sUA) less than 6 mg per dL after 2 weeks with 40 mg, Febuxostat 80 mg is recommended.

No dose adjustment is necessary when administering Febuxostat to patients with mild to moderate renal or hepatic impairment.

Use in Children
Safety and efficacy in children below the age of 12 years have not been studied.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

Pack Size & Price