Lotepro Plus (Eye Drops)
Manufactured by: Incepta Pharmaceuticals Ltd.
Loteprednol Etabonate 0.5% + Tobramycin 0.3% Eye prep Similar medicine
Lotepro Plus is indicated for
- Keratitis
- Allergic conjunctivitis
- Iritis
- Ocular inflammation
- Bacterial ocular infection
- Cyclitis
Precautions and warnings
- Shake the bottle well before each use.
- Don’t let the tip of the dropper touch your eye, eyelid, fingers, or any surface to avoid contamination.
- Do not wear soft contact lenses while using this medication.
- If you use this product for 10 days or more, your eye pressure should be checked regularly.
- Long-term use of steroids can increase the risk of fungal infections in the cornea.
- Using steroids after cataract surgery can slow down the healing process.
- If another infection develops while using this medication, start appropriate treatment.
Side-effects
- Prolonged use may increase: IOP
- which may be associated with possible development of glaucoma
- infrequent optic nerve damage; posterior sub-capsular cataract formation
- perforation of the globe where there is thinning of the cornea or sclera. The most frequent adverse reactions to topical tobramycin are hypersensitivity
- localized ocular toxicity
- including lid itching
- swelling
- conjunctival erythema.
Drug Interactions
Combining this medicine with other aminoglycosides (such as amikacin or streptomycin), cefaloridine, viomycin, polymyxin B, colistin, cisplatin, or vancomycin can increase the risk of damage to the nerves and kidneys. Using it with strong diuretics like ethacrynic acid or furosemide can also make these side effects worse. If given to patients under anesthesia who are also receiving muscle relaxants (such as succinylcholine, tubocurarine, or decamethonium), it may cause longer-lasting breathing problems. The risk of kidney damage is higher if used with ciclosporin or certain other antibiotics (like cephalosporins). Medicines like neostigmine and pyridostigmine may reduce its effects. This medicine can also increase the action of blood thinners like warfarin and phenindione.
Contraindications
This eye drop, like other steroid and antibiotic combination eye medicines, should not be used for most viral infections of the cornea and conjunctiva. This includes conditions such as epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and chickenpox (varicella). It is also not safe for people with mycobacterial or fungal infections in the eye. In addition, people who are allergic or sensitive to any of the ingredients in this eye drop, or to other corticosteroids, should not use it.
Mode of actions
Loteprednol is an artificial steroid medicine that is not fluorinated. It works by increasing the amount of special proteins called lipocortins, which help control inflammation by affecting certain chemicals in the body.
Tobramycin is an antibiotic that works by attaching to part of the bacteria called the 30S ribosomal subunit, which stops the bacteria from making proteins they need to grow. It is effective against many types of bacteria that need oxygen to survive, including some that are gram-positive and many that are gram-negative. However, it does not work against Chlamydia, fungi, viruses, or most bacteria that do not need oxygen.
Dosage & Administration
Shake the bottle vigorously before using.
Apply 1 or 2 drops of Lotepro plus into the conjunctival sac of the affected eye(s) every 4 to 6 hours.
During the initial 24 to 48 hours, the dosing may be increased, to every 1 to 2 hours. Frequency should be decreased gradually as warranted by improvement in clinical signs. Care should be taken not to discontinue therapy prematurely.
Pediatric Use: Safety and effectiveness in pediatric patients have not been established.
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.
Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.
This medicine passes into breast milk. Talk to your doctor before breastfeeding.
Pack Size & Price
5 ml drop Price : ৳200
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