Precautions and warnings

If you are allergic to metformin or have any other allergies, consult your doctor before using this drug. Inactive chemicals may be included in this product, causing allergic reactions or other issues. For further information, speak with your pharmacist.

Tell your doctor if you have severe breathing issues, obstructive lung disease, severe asthma, anemia, vitamin B12 deficiency, kidney illness, or liver disease before using this drug.

Due to excessively low or high blood sugar, you may feel blurred vision, dizziness, or drowsiness. Do not drive, operate machinery, or engage in any activity that necessitates alertness or clear vision until you are certain you can do so safely.

While using this medication, you should avoid drinking alcohol because it can cause lactic acidosis and low blood sugar.

Excessive sweating, diarrhea, or vomiting might dehydrate you and put you at risk for lactic acidosis. If you experience extended diarrhea or vomiting, stop taking this medication and contact your doctor right away. Unless your doctor tells you otherwise, make sure you drink plenty of water to avoid dehydration.

When your body is stressed from a fever, infection, injury, or surgery, it may be more difficult to maintain blood sugar control. Increased stress may necessitate a change in your treatment plan, medications, or blood sugar tests, so talk to your doctor.

Metformin can alter your menstrual cycle, boost ovulation, and raise your chances of getting pregnant. While using this medicine, talk to your doctor about utilizing a reliable birth control method.

Drug Interactions

Beta-blockers like metoprolol and propranolol, as well as glaucoma eye medicines like timolol, can help you avoid the fast pulse that occurs when your blood sugar drops too low. These medications have little effect on other symptoms of low blood sugar, such as dizziness, hunger, or sweating.

Many medications might have an adverse effect on your blood sugar, making it more difficult to manage. Consult your doctor or pharmacist before beginning, stopping, or changing any medication to learn how it may impact your blood sugar. Check your blood sugar as prescribed and inform your doctor of the results. If you have symptoms of high or low blood sugar, call your doctor straight once. Your diabetic medication, exercise routine, or diet may need to be adjusted by your doctor.

Contraindications

Metabolic acidosis, acute or chronic, with or without coma (including diabetic ketoacidosis). Renal failure, severe renal or hepatic impairment, and acute diseases such as dehydration, severe infection, or shock can all decrease renal function. Acute or chronic alcoholism, cardiac failure, CHF, IDDM, severe thyroid dysfunction, severe impairment of thyroid function Tissue hypoxia can be caused by acute or chronic illnesses, such as cardiac or respiratory failure, recent MI, or shock. A mother who breastfeeds her baby during pregnancy.

PO Type 2 (adult) Initial dose: 500 mg 2-3 times per day, with the possibility of gradually increasing. 2.25 gm/day maximum.

Polycystic ovarian syndrome (PCOS) is a type of polycystic ova. For the first week, take 500 mg in the morning, then 500 mg twice day for another week.

Mode of actions

Metformin is an antihyperglycemic biguanide that lowers both basal and postprandial plasma glucose levels. It inhibits gluconeogenesis and glycogenolysis in the liver, slows glucose absorption in the intestine, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

Dosage & Administration

The usual starting dose is 500 mg twice daily or 850 mg once a day, given with meals. Dosage increase should be made in increments of 500 mg weekly or 850 mg every 2 weeks up to a total of 2000 mg per day, given in divided doses.

Patients can be titrated from 500 mg twice a day to 850 mg twice a day after 2 weeks. For these patients requiring additional glycaemic control, metformin may be given to a maximum daily dose of 2550 mg per day.

Doses above 2000 mg may be better tolerated when given three times a day with meals. The usual starting dose of Metformin HCl extended - release tablet is 500 mg once daily with the evening meal. Dosage increase may be made up to a max. of 2000 mg once daily with the evening meal.

Polycystic ovary syndrome Initial: 500 mg/day in the morning for 1 wk, then 500 mg twice daily for 1 wk, then 1.5-1.7 g/day in 2-3 divided doses.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.

Discuss with your doctors and tell them feedback about this medicine.

There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.

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