Perigen IM 5mg/ml (Injection)
Manufactured by: General Pharmaceuticals Ltd.
Haloperidol Similar medicine
Perigen IM is indicated for
- Schizophrenia
- Delirium
- Hiccups
- Acute psychosis
- Hyperactivity
- Aggression
- Agitation
- confusion
- Tic disorders
- Tourette syndrome
- Chorea
- Nausea
- vomiting
- Dementia.
Precautions and warnings
People with the following conditions should be cautious: Parkinsonism; epilepsy; allergies; angle-closure glaucoma; benign prostatic hyperplasia; serious heart or liver problems; extreme temperatures (very hot or cold weather); ongoing infections or low white blood cell count; overactive thyroid; pregnancy; elderly age or very young children. Extra care is needed for patients taking blood thinners. If neurological side effects appear in patients using both haloperidol and lithium, stop the medication immediately.
Side-effects
- Tardive dyskinesia; extrapyramidal reactions. Anxiety
- drowsiness
- depression
- anorexia
- transient tachycardia
- postural hypotension
- leukopenia; anticholinergic side effects.Potentially Fatal: Neuroleptic malignant syndrome
Drug Interactions
Carbamazepine and rifampicin lower the amount of this drug in the blood. Other medicines that slow down the brain, such as alcohol, sleeping pills, anesthetics, anxiety medicines, and strong painkillers, can make side effects like drowsiness worse. This drug may also make guanethidine, a blood pressure medicine, less effective. There is a higher risk of heart rhythm problems if taken with medicines that affect the heart’s QT interval or with diuretics that disturb body salts. Using this medicine with clozapine or chlorpromazine may raise haloperidol levels in the blood.
Serious Warning: This drug can increase lithium levels in the blood and may cause a dangerous reaction known as neuroleptic malignant syndrome.
Contraindications
Serious poisoning that causes strong depression of the central nervous system; already being in a coma; having Parkinson’s disease; or currently breastfeeding.
Mode of actions
Haloperidol works by blocking dopamine D1 and D2 receptors in the brain’s mesolimbic system. It also lowers the release of certain hormones from the hypothalamus and pituitary gland. As a result, haloperidol helps people feel calmer, reduces aggressive behavior, and makes hallucinations and delusions go away.
Dosage & Administration
Adult: PO Psychoses 0.5-5 mg 2-3 times/day, up to 100 mg/day in severe cases. Maintenance: 3-10 mg/day.
Severe tics; Tourette's syndrome Initial: 0.5-1.5 mg 3 times/day, up to 10 mg/day in Tourette's syndrome.
Adjunct in severe anxiety or behavioral disturbances 0.5 mg twice daily.
Restlessness and confusion 1-3 mg 8 hrly.
Intractable hiccup 1.5 mg 3 times/day.
Intramuscular:
Acute psychosis 2-10 mg hrly or 4-8 hrly until symptoms are controlled. Max: 18 mg/day.
Nausea and vomiting 0.5-2 mg/day.
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.
Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.
This medicine passes into breast milk. Talk to your doctor before breastfeeding.
Pack Size & Price
10's pack Price : ৳120
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There are few similar medicines of Perigen IM are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
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