Remus 0.1%, 0.03% (Ointment)
Manufactured by: Square Pharmaceuticals Ltd.
Tacrolimus 0.1%, 0.03% Topical Similar medicine
Remus is indicated for
- 異位性皮膚炎、過敏性接觸性皮膚炎、嚴重濕疹、牛皮癬、斑禿、壞疽性膿皮病、皮膚紅斑狼瘡、皮肌炎、脂漏性皮膚炎、紅斑痤瘡、扁平苔癬、尋常型天皰瘡、白斑症、移植物抗宿主疾病、魚鱗病。
Precautions and warnings
當使用他克莫司軟膏治療可能發生皮膚感染的異位性皮膚炎患者時，需要謹慎。 對於皮膚廣泛發紅（全身性紅皮症）的人來說，他克莫司軟膏的安全性尚未得到證實。
Side-effects
- 外用他克莫司軟膏的副作用非常少且罕見，包括皮膚灼熱感、搔癢、流感樣症狀、過敏反應、皮膚紅斑、皮膚感染、頭痛等。
Drug Interactions
如果與環孢素、氨基糖苷類、兩性黴素 B、順鉑、非類固醇抗發炎藥、萬古黴素、複方新諾明、阿昔洛韋或更昔洛韋等其他藥物一起服用，他克莫司對腎臟的危害更大。 與保鉀利尿劑一起使用時，高鉀水平的風險也較高。 有些藥物（例如唑類抗黴菌藥物、鈣通道阻斷劑、西咪替丁、達那唑、HIV 蛋白酶抑制劑、大環內酯類抗生素和甲氧氯普胺）會增加血液中他克莫司的濃度，進而增加副作用。 另一方面，抗酸劑、利福平、利福布丁、卡泊芬淨、苯妥英、苯巴比妥和卡馬西平等藥物可以降低他克莫司的水平，從而降低其療效。 一起服用西羅莫司和他克莫司可以降低兩種藥物的含量。
Contraindications
對他克莫司或軟膏中任何其他成分過敏的人不應使用他克莫司軟膏。
Mode of actions
他克莫司的作用是阻止 T 淋巴細胞（一種免疫細胞）變得活躍，但其確切方法尚不完全清楚。 它附著在細胞內某些稱為親免素的蛋白質上，例如 FK 結合蛋白 12 (FKBP-12)。 這種連接產生複合物，透過稱為鈣調神經磷酸酶的途徑阻止訊號蛋白（細胞激素）的產生。 透過阻斷鈣調神經磷酸酶，他克莫司可防止 T 細胞過早激活，進而導致免疫活性降低（免疫抑制）。
Dosage & Administration
將一薄層他克羅姆軟膏塗抹在受影響的皮膚區域，每天兩次，然後輕輕地、徹底地揉搓。 異位性皮膚炎的徵兆和症狀消失後，應繼續治療一週。 他克羅姆軟膏在可能促進全身暴露的閉塞狀態下的安全性尚未得到評估。 他克洛姆軟膏不應與封閉敷料一起使用。
Pregnancy & Lactation
雖然動物生殖研究顯示對胎兒有不良影響，並且在孕婦中沒有充分且良好對照的研究，但在懷孕期間，儘管存在潛在風險，但在確實需要時可以使用該藥物。
在懷孕最後 3 個月內使用這種藥物的新生兒母親可能很少會出現困倦、肌肉僵硬或顫抖、餵食或呼吸困難、持續哭泣等症狀。 如果您發現寶寶有任何這些症狀，尤其是在第一個月內，請立即告訴醫生。
這種藥物會進入母乳。 哺乳前請先諮詢您的醫生。
Pack Size & Price
5gm tube / 5gm tube Price : ৳80.30 / 200
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