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Clozosone 0.0005 (Cream)

Manufactured by: Unimed & Unihealth Manufacturers Ltd.

Betamethasone 0.1% + Clotrimazole 1% Topical Similar medicine

Clozosone is indicated for

  • Tinea pedis
  • tinea cruris
  • tinea corporis
  • ringworm
  • athlete's foot
  • jock itch.

Precautions and warnings

Topical corticosteroids can cause a reversible suppression of the hypothalamic-pituitary-adrenal (HPA) axis, which can lead to glucocorticosteroid insufficiency if treatment is stopped. Cushing's syndrome, hyperglycemia, and glucosuria can all be caused by systemic absorption of topical corticosteroids while on treatment in some patients.

Usage over broad surface regions, continuous use, and use under occlusive dressings are all conditions that increase systemic absorption.

If HPA axis suppression is detected, the medicine should be discontinued, the frequency of application reduced, or a less potent corticosteroid substituted.

Due to their greater skin surface-to-body mass ratios, pediatric patients may be more sensitive to systemic toxicity from equal doses.

Side-effects

  • Adverse reactions reported for Clotrimazole
  • Betamethasone Dipropionate Cream in clinical trials were paresthesia in 1.9% of patients
  • and rash
  • edema
  • and secondary infection
  • each in less than 1% of patients. The following local adverse reactions have been reported with topical corticosteroids
  • may occur more frequently with the use of occlusive dressings. In the pediatric population
  • reported adverse events for Clotrimazole
  • Betamethasone Dipropionate Cream include growth retardation
  • benign intracranial hypertension
  • Cushing's syndrome (HPA axis suppression)
  • and local cutaneous reactions
  • including skin atrophy. Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression
  • manifestations of Cushing's syndrome
  • hyperglycemia
  • and glucosuria in some patients. Adverse reactions reported with the use of clotrimazole are as follows: erythema
  • stinging
  • blistering
  • peeling
  • edema
  • pruritus
  • urticaria
  • and general irritation of the skin.

Contraindications

Patients who are allergic to clotrimazole, betamethasone dipropionate, other corticosteroids, imidazoles, or any other substance in these products.

Mode of actions

Betamethasone is a corticosteroid that primarily acts as a glucocorticoid. It reduces the rate of protein synthesis, inhibits the migration of polymorphonuclear leukocytes and fibroblasts, and reverses capillary permeability and lysosomal stabilization to prevent and regulate inflammation.

Clotrimazole is a fungal antifungal drug that binds to phospholipids in the cell membrane of the fungus. By changing cell wall permeability, it causes the loss of critical intracellular components.

Dosage & Administration

Gently massage sufficient Clotrimazole and Betamethasone Dipropionate Cream into the affected skin areas twice a day, in the morning and evening.

Pregnancy & Lactation

This medicine is not allowed during pregnancy. Do not use it if you are pregnant. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict effective birth control during treatment and for six months after stopping this medicine. If you do become pregnant, stop taking this medicine and discuss your doctor right away.

There is no specific information on whether this medicine passes into breast milk or not. Considering the possible risks for the children, breastfeeding while using this medicine is not recommended and at least two weeks after the last dose. Consult your doctor before breastfeeding.

Pack Size & Price

1's pack (10g) Price : ৳25

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There are few similar medicines of Clozosone are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.