Xitabin 500mg (Tablet)
Manufactured by: Beacon Pharmaceuticals Ltd.
Capecitabine Similar medicine
Xitabin is indicated for
- Breast cancer
- Colorectal cancer
- Gastric cancer
- Oesophageal cancer
Precautions and warnings
Liver problems, reduced bone marrow function, poor nutrition, and taking warfarin can increase risks. Children, older adults, and people who have had extensive pelvic radiation or certain cancer therapies are also at higher risk. Use caution in those with moderate kidney problems. It’s important to check blood counts (CBC with differential) and monitor liver and kidney function regularly. Stop using the medication if persistent diarrhea, mouth sores, serious bone marrow problems, or a heart attack occur.
Side-effects
- Diarrhoea
- nausea
- vomiting
- stomatitis
- palmar-plantar syndrome
- dermatitis. Fatigue
- mucosal inflammation
- pyrexia
- asthenia
- lethargy; headache
- dizziness
- insomnia; lower limb oedema
- anorexia
- dehydration. Potentially Fatal: Cardiotoxicity
- bone-marrow depression
- hyperbilirubinaemia.
Drug Interactions
- Antacids that have aluminum and magnesium
- Leucovorin
- Anticoagulants (blood thinners)
- Phenytoin
- Allopurinol
Contraindications
People who have had serious or unexpected reactions to fluoropyrimidine treatment, those with severe kidney problems, pregnant or breastfeeding women, and anyone with allergies to these medicines should not use them.
Mode of actions
Capecitabine is a medication that is taken by mouth and turns into another drug called fluorouracil once inside the body. Fluorouracil works by blocking an enzyme needed to make DNA, which stops cancer cells from growing and dividing. It also affects RNA production, but to a lesser extent.
Dosage & Administration
Adult: PO Colorectal cancer; Breast cancer 1.25 g/m2 twice daily for 14 days followed by a 7-day rest period. Treatment duration for colorectal cancer: 6 mth. Gastric cancer W/ platinum-based compd: 1 g/m2 twice daily for 14 days, followed by a 7-day rest period.
Renal impairment:
CrCl (ml/min)
51-80 No adjustment needed.
30-50 Reduce dose to 950 mg/m2 bid when starting dose is 1.25 g/m2 bid. No dose adjustment is needed when starting dose is 1 g/m2.
Pregnancy & Lactation
This medicine is not allowed during pregnancy. Do not use it if you are pregnant. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict effective birth control during treatment and for six months after stopping this medicine. If you do become pregnant, stop taking this medicine and discuss your doctor right away.
There is no specific information on whether this medicine passes into breast milk or not. Considering the possible risks for the children, breastfeeding while using this medicine is not recommended and at least two weeks after the last dose. Consult your doctor before breastfeeding.
Pack Size & Price
1's pack Price : ৳125
Similar medicine
Manufactured by: Beacon Pharmaceuticals Ltd.
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Click here to see more similar medicines
There are few similar medicines of Xitabin are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
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