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Trimela (Cream)

Manufactured by: Incepta Pharmaceuticals Ltd.

Fluocinolone 0.01% + Hydroquinone 4% + Tretinoin 0.05% Topical Similar medicine

Trimela is indicated for

  • Melasma

Precautions and warnings

Cream contains hydroquinone and tertian that may cause mild to moderate irritation such as skin reddening, peeling, mild burning sensation, dryness, and pruritus, Transient skin reddening or mild burning sensation does not prevent treatment, If a reaction suggests hypersensitivity or chemical irritation, the use of the medication should be discontinued.

Cream also contains the corticosteroid fluocinolone acetone, Systemic absorption of topical corticosteroids can raise changeable neural structure-pituitary-adrenal (HPA) axis suppression with the likely for glucocorticosteroid insufficiency after withdrawal of treatment, Manifestations of Cushing's syndrome, hyperglycemia, and glycosuria can also be produced by systemic absorption of topical corticosteroid while on treatment, If HPA axis suppression is illustrious, Cream should be discontinued.


  • The most frequently reported events were erythema
  • desquamation
  • burning
  • itching
  • irritation
  • dryness
  • hypopigmentation
  • perioral dermatitis
  • allergic contact dermatitis
  • secondary infection
  • and skin atrophy at the site of application. The majority of these events were mild to moderate in severity.

Drug Interactions

Medicated or harsh soaps and amp; cleansers, soaps and amp; cosmetics along with drying effects, products along with high con of alcohol and amp; sour, and amp; other irritants or keratolytic drugs, Medications along with photosensitizing effects.


A history of hypersensitivity, allergy, or intolerance to this product or any of its components.

Mode of actions

Fluocinolone acetone is a agglutinative fluorinated corticosteroid that is used topically for its opposed-inflammatory, anti-pruritic and vasoconstrictive properties, Hydroquinone is used as a depigmenting agent, Tertian is a retinoid that is appears to stimulate mitosis, increases turnover of follicular epithelial cells and reduces their cohesiveness.

Dosage & Administration

It should be applied at least 30 minutes before bedtime. A thin film of the cream should be applied to the hyperpigmented areas of melasma including about ½ inch of normal appearing skin surrounding each lesion.

Cream is for short-term (up to 8 weeks) treatment of moderate to severe melasma of the face. It is not for long-term (more than 8 weeks) or maintenance (continuous) treatment of melasma.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

Pack Size & Price

30gm tube Price : ৳200

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Manufactured by: Pharmasia Ltd.

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Melatril (Cream)

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Click here to see more similar medicines

There are some similar medicines of Trimela are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.


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