Drug Interactions

ACE inhibitors, angiotensin II receptor blockers, and beta-blockers may not work as well at lowering blood pressure. Some diabetes medicines (like glyburide and metformin) may slightly lower blood sugar levels more in diabetic patients. Furosemide and thiazide diuretics may not be as effective. Lithium and methotrexate may become more toxic. The risk of bleeding may increase if you are also taking antiplatelet drugs, blood thinners, SSRIs, or corticosteroids.

Contraindications

Peptic ulcers, bleeding in the stomach or intestines, asthma, difficulty breathing (bronchospasm), runny or stuffy nose (rhinitis), swelling under the skin (angioedema), allergies or sensitivity to certain medications, intolerance to aspirin, pregnancy during the third trimester, and breastfeeding.

Mode of actions

Flurbiprofen works by lowering the activity of an enzyme called cyclooxygenase, which leads to less production of prostaglandins in the body. This results in lower prostaglandin levels. In addition, flurbiprofen strongly reduces the clumping together of platelets.

Dosage & Administration

Adult: PO Pain and inflammation associated w/ musculoskeletal and joint disorders 150-200 mg/day in divided doses, up to 300 mg/day in severe cases.
Dysmenorrhoea Initial: 100 mg, then 50-100 mg 4-6 hrly. Max: 300 mg/day.
Sore throat Per loz contains 8.75 mg flurbiprofen: 1 loz 3-6 hrly, up to a max of 3 days. Max: 5 loz/day.
Ophth Prevention of miosis during ocular surgery As 0.03% flurbiprofen Na soln: Instill 1 drop every 30 mins starting 2 hr before and ending not

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

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