Holoxan 1gm (Injection)
Manufactured by: Sanofi Aventis (BD) Ltd.
Ifosfamide Similar medicine
Holoxan is indicated for
- Breast cancer
- Lung cancer
- Ovarian cancer
- Lymphoma
- Testicular cancer
- Soft tissue sarcoma
- Osteogenic sarcoma
- Cervical cancer
Precautions and warnings
Liver or kidney problems, or weak bone marrow. Use this medicine with mesna and make sure to drink plenty of fluids (by mouth or IV) to help prevent bladder side effects.
Side-effects
- Confusion
- alopoecia
- nausea
- vomiting
- phloebitis
- somnolence
- depression
- hallucinations. Wound healing may be impaired during ifosfamide use. Potentially Fatal: Severe myelosuppression
- haemorrhagic cystitis
- nephrotoxicity
- cardiotoxicity
- coma.
Drug Interactions
Ifosfamide can be more toxic when taken with allopurinol or cisplatin. It can also make warfarin work more strongly, increasing its blood-thinning effects. Some drugs that speed up the CYP2A6 enzyme, such as amobarbital, phenobarbital, pentobarbital, rifampin, and secobarbital, may lower the amount of ifosfamide in your blood. In contrast, drugs that slow down this enzyme, like isoniazid, methoxsalen, and miconazole, can raise ifosfamide levels.
Similarly, drugs that increase CYP3A4 activity — such as aminoglutethimide, carbamazepine, nafcillin, nevirapine, phenobarbital, phenytoin, and rifamycins — may also lower ifosfamide levels in the blood. On the other hand, drugs that block CYP3A4 — like azole antifungals, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, and isoniazid — may raise ifosfamide levels.
Contraindications
Hypersensitivity; severe bone-marrow depression. Pregnancy, lactation.
Mode of actions
Ifosfamide is changed by liver enzymes into active forms that work as alkylating agents, which interfere with the DNA and protein production in target cells. To help prevent damage to the bladder and urinary tract, it is usually given together with mesna.
Dosage & Administration
Adult: IV Lymphoma; Sarcoma; Solid tumours Different licensed dosage regimens are available. 8-12 g/m2 divided over 3-5 days, repeat course 2-4 wkly.
Germ cell testicular carcinoma W/ mesna and adequate hydration: 1.2 g/m2/day for 5 days, repeat treatment 3 wkly or after recovery from haematological toxicity.
Renal impairment:
CrCl (ml/min)
Pregnancy & Lactation
This medicine is not allowed during pregnancy. Do not use it if you are pregnant. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict effective birth control during treatment and for six months after stopping this medicine. If you do become pregnant, stop taking this medicine and discuss your doctor right away.
There is no specific information on whether this medicine passes into breast milk or not. Considering the possible risks for the children, breastfeeding while using this medicine is not recommended and at least two weeks after the last dose. Consult your doctor before breastfeeding.
Pack Size & Price
1's pack Price : ৳3049.8
Similar medicine
Manufactured by: Techno Drugs Ltd.
Manufactured by: Sanofi Aventis (BD) Ltd.
Manufactured by: Sanofi Aventis (BD) Ltd.
Manufactured by: Techno Drugs Ltd.
Click here to see more similar medicines
There are few similar medicines of Holoxan are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
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