Precautions and warnings

Extrapyramidal syndrome, low blood pressure, epilepsy, and problems with the liver, kidneys, heart, brain, or lungs. Also includes glaucoma. This medicine may affect your ability to drive or do activities that need you to be alert or have good coordination. It is not recommended to give this medicine by injection to children. Use with caution if you have a history of jaundice, Parkinson’s disease, diabetes, underactive thyroid, myasthenia gravis, blocked intestines, enlarged prostate, or trouble urinating. If you use this medicine for a long time, regular eye check-ups are advised.

Drug Interactions

Alcohol and antacids.

Contraindications

CNS depression or coma. Bone marrow suppression, pheochromocytoma, prolactin-dependent tumors, or if you have an allergy to this medication. Not for children.

Mode of actions

Antiemetic: Works by blocking dopamine receptors in the brain and the vagus nerve in the digestive tract, helping to prevent nausea and vomiting.

Antipsychotic: Works by blocking dopamine receptors (especially in the mesolimbic area) and alpha-adrenergic receptors (D1 and D2) in the brain to help control symptoms of psychosis.

Dosage & Administration

IV/IM:
Nausea and vomiting
Adult: As mesilate: 12.5 mg by deep IM. If required, may give further doses via oral admin.
Severe nausea and vomiting
Adult: 2.5-10 mg via slow IV inj or infusion at a rate not exceeding 5 mg/minute. Not to exceed 40 mg daily.

Psychoses
Adult: As mesilate: 12.5-25 mg by deep IM Inj bid/tid.

Oral
Prophylaxis of nausea and vomitting
Adult: As mesilate: 5-10 mg bid/tid. May also be given rectally.

Nausea and vomiting
Adult: As mesilate: 20 mg, further doses are given if needed. Recommended buccal dose: As maleate: 3-6 mg bid.

Psychoses
Adult: As mesilate: 12.5 mg bid for 7 days, adjusted gradually to 75-100 mg daily according to response. Usual maintenance dose: 25-50 mg daily.
Child: 1-5 yr: 1.25-2.5 mg; 5-12 yr: 2.5-5 mg. May be given up to tid, if necessary.

Adjunct in severe anxiety disorders
Adult: As mesilate: 5-10 mg, up to 3-4 times daily.

Vertigo
Adult: As mesilate: 15-30 mg daily, given in divided doses. May reduce gradually to 5-10 mg daily. Recommended buccal dose: 3-6 mg bid.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

Pack Size & Price