Premarin 0.625mg (Tablet)
Manufactured by: Pfizer Pharmaceuticals, Ireland
Estrogens Similar medicine
Premarin is indicated for
- Breast cancer
- Prostate cancer
- Hormone replacement therapy
- Oral contraceptives
Precautions and warnings
Asthma, epilepsy, and migraine; problems with the heart or kidneys; cardiovascular disease; stroke or other cerebrovascular conditions; diabetes; high calcium levels in the blood; gallbladder disease; porphyria. Use with caution in children and during breastfeeding.
Side-effects
- Abnormal bleeding; vomiting
- nausea; tender breasts
- wt gain
- fluid retention; headache
- depression. Males: Gynaecomastia
- impotence. Potentially Fatal: Unopposed replacement therapy in postmenopausal women associated with increased risk of endometrial
- breast cancer.
Drug Interactions
Rifampicin and barbiturates increase how quickly the drug is broken down in the body.
Warning: These drugs may make anticoagulants (medicines that prevent blood clots) less effective, which could be very dangerous.
Contraindications
Do not use if you have severe liver problems, breast cancer, blood clots, heart or blood vessel disease, unexplained vaginal bleeding, tumors that depend on estrogen, allergies to this medication, or if you are pregnant.
Mode of actions
Estrogens control the release of gonadotropins, luteinising hormone, and follicle-stimulating hormone from the pituitary gland by using a negative feedback process. This helps lower the high hormone levels that can occur in postmenopausal women during estrogen replacement therapy.
Dosage & Administration
Adult: PO Menopausal vasomotor symptoms 0.45 mg/day, up to 1.25 mg/day. Attempt to discontinue medication at 3-6-mth intervals.
Vulvular and vag atrophy 0.3 mg/day. Female hypogonadism 0.3-0.625 mg/day in a cyclical regimen. Add progestin treatment once skeletal maturity is achieved.
Female castration; Primary ovarian failure 1.25 mg/day in a cyclical regimen.
Palliation in prostate carcinoma 1.25-2.5 mg 3 times/day.
Osteoporosis prophylaxis in postmenopausal women Initial: 0.3 mg/day in a cyclical or continuous regimen depending on patient's condition.
Pregnancy & Lactation
FDA has not yet classified this medicine into a specified pregnancy category. Although there is no enough evidence that taking this medicine during you are pregnant is harmful.
Discuss with your doctor if you are trying to get pregnant while taking this medicine too.
If you do become pregnant while you are taking this medicine, you should continue to take it and contact with your doctors as quickly as possible. They can assist you to decide whether or not to keep taking this medicine. If you abandon taking this medicine and become sick, this would be more pernicious to your child than staying on the medication.
There is no specific information about whether this medicine is passed on to the baby through breast milk. During this medication, if your baby becomes very sleepy, restless, fatigued, exhibit feeding problems, stop breastfeeding and talk to your doctors very quickly.
Pack Size & Price
0.625mg x 100's pack Price : ৳202.6
Similar medicine
Manufactured by: Pfizer Pharmaceuticals, Ireland
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There are few similar medicines of Premarin are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
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