Precautions and warnings

Use with caution in pregnant or breastfeeding women, people with heart disease, overactive thyroid, liver or kidney problems, or an enlarged prostate. Also, be careful in cases of diarrhea, fever, and in patients with ulcerative colitis, as this medicine may cause ileus or megacolon. Extra care is needed when giving to children and older adults.

Contraindications

Do not use this medicine if you are allergic to it, have glaucoma, blocked urine flow, or any blocked digestive conditions like intestinal paralysis, paralytic ileus, or pyloric stenosis. It should also be avoided if you have myasthenia gravis or unstable heart and blood vessel conditions, especially during acute bleeding. Injectable forms should not be given to newborns.

Mode of actions

Glycopyrronium bromide is a type of antimuscarinic medicine that belongs to the quaternary ammonium group. It works by blocking the action of acetylcholine at certain nerve sites, causing smooth muscles to relax. This drug also lowers the production of stomach acid and helps control secretions in the throat, windpipe, and airways. In addition, it helps prevent unwanted symptoms caused by some medications, such as too much mucus in the lungs, breathing spasms, slow heart rate, and excessive movement in the intestines.

Dosage & Administration

Parenteral
Reduction of secretions
Adult: Preoperative: 4 mcg/kg via IM admin 30-60 minutes before procedure. Intraoperative: 0.1 mg via IV admin, repeat at 2-3 minute intervals when needed. Max: 400 mcg/dose.
Child: Preoperative: IM admin: 2 yr: 4 mcg/kg, dose to be given 30-60 minutes before procedure. Intraoperative: IV admin: 4 mcg/kg (Max: 0.1 mg); repeat at 2-3-minute intervals as needed.
Max Dosage: Adult: 400 mcg/dose. Child >1 mth: 200 mcg/dose.
Intravenous
Reversal of neuromuscular blockade
Adult: 200 mcg for each 1 mg of neostigmine or 5 mg of pyridostigmine. Alternatively, 5-15 mcg/kg with 50 mcg/kg neostigmine with 25-70 mcg/kg of neostigmine or 0.1-0.3 mg/kg of pyridostigmine.
Child: 10 mcg/kg with 50 mcg/kg neostigmine.
Parenteral
Peptic ulcer
Adult: 0.1-0.2 mg 3-4 times daily via IM/IV admin.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.

Discuss with your doctors and tell them feedback about this medicine.

There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.

Pack Size & Price