Precautions and warnings

During pregnancy, insulin needs usually decrease in the first trimester, then increase in the second and third trimesters. Insulin requirements may also change during breastfeeding. It is important to regularly check HbA1c levels and blood sugar.

Drug Interactions

Some medicines can lower the amount of insulin you need, including oral diabetes drugs, MAOIs, nonselective beta-blockers, ACE inhibitors, painkillers like salicylates, alcohol, anabolic steroids, and sulphonamides. Other medicines, such as oral contraceptives, thiazide diuretics, steroids (glucocorticoids), thyroid hormones, drugs that mimic adrenaline (beta-sympathomimetics), and danazol, can raise your insulin needs.

Drugs like octreotide or lanreotide can either increase or decrease your insulin needs. Beta-blockers can also hide the signs of low blood sugar. Alcohol can either make insulin work too strongly or not strongly enough.

Contraindications

Hypoglycaemia.Hypersensitivity to any of the components.

Mode of actions

Insulin helps lower blood sugar levels. It controls how the body handles carbohydrates, proteins, and fats by stopping the liver from making too much glucose, reducing the breakdown of fats, and helping the body use glucose more effectively. There are different types of insulin, classified by how long they work after being injected under the skin (subcutaneous or SC injection). These types include short-acting, intermediate-acting, and long-acting insulin. Soluble insulin (also called 'neutral' or 'regular' insulin) is a short-acting type.

To make insulin last longer in the body, it can be prepared in suspensions using two main methods. The first method mixes insulin with a protein, so it is released slowly. Examples include protamine zinc insulin (which has extra protamine) and isophane insulin (NPH insulin, which has equal parts protamine and insulin). The second method changes the size of the insulin particles, such as in insulin zinc suspensions. All these types can be injected under the skin, and most can also be injected into the muscle (IM injection). However, only soluble insulin can be given by vein (IV injection). Compared to under-the-skin injections, injecting insulin into the muscle works faster but doesn't last as long.

Dosage & Administration

Adult: SC DM Dosage should be individualised and adjusted based on patient's glycaemic response. Usual range: 0.5-1 u/kg/day.
Morning: Give 2/3rds of daily insulin SC
Ratio of regular insulin to NPH (isophane) insulin 1:2

Evening: Give 1/3 of daily insulin SC

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.

Discuss with your doctors and tell them feedback about this medicine.

There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.

Pack Size & Price