Xorel 20mg (Tablet)
Manufactured by: Ibn Sina Pharmaceutical Ind. Ltd.
Rabeprazole Similar medicine
Xorel is indicated for
- Peptic ulcer disease
- H. pylori infection
- Gastro-oesophageal reflux disease
- Paediatric GERD
Precautions and warnings
Do not split, chew, or crush Rabeprazole Sodium tablets.
Side-effects
- In general
- Rabeprazole is well-tolerated in both short-term
- long-term studies. Rabeprazole may some times cause headache
- diarrhoea
- abdominal pain
- vomiting
- constipation
- dry mouth
- increased or decreased appetite
- muscle pain
- drowsiness
- dizziness.
Drug Interactions
This medication may lower the amount of ketoconazole, itraconazole, and clopidogrel in your blood. Taking it with diuretics or digoxin can raise the risk of low magnesium levels. It may also make warfarin work more strongly, increasing prothrombin time and INR. It can raise the levels of saquinavir and methotrexate in your blood, but sucralfate can lower its own levels.
Serious Warning: It may reduce the amount and effect of rilpivirine and atazanavir, which can be dangerous.
Contraindications
Rabeprazole should not be used by people who are allergic to Rabeprazole, other proton pump inhibitors (PPIs), or any of the ingredients in the medicine.
Mode of actions
Rabeprazole is a type of medicine called a proton pump inhibitor (PPI). It reduces the amount of acid the stomach makes by blocking an enzyme called H+/K+ ATPase, which is found on the surface of certain stomach cells.
Dosage & Administration
i) Duodenal ulcer: 20 mg tablet in the morning is indicated for 4 weeks treatment in the healing and symptomatic relief of duodenal ulcer. Most patients heal within 4 weeks.
ii) Benign gastric ulcer: 20 mg daily in the morning for 6 weeks, followed by a further 6 weeks if not fully cured.
iii) Duodenal ulcer and benign gastric ulcer associated with H. pylori infection: Rabeprazole in combination with Amoxicillin and Clarithromycin as a three drug regimen is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease. Rabeprazole offers a faster therapy option than other PPIs, up to 10 to 14 days 20 mg once daily.
iv) Healing of erosive or ulcerative Gastroesophageal Reflux Disease (GERD): 20 mg daily in the morning 4 to 8 weeks. Those patients who have not healed after 8 weeks of treatment, an additional 8-week course of Rabeprazole may be considered.
v) Treatment of symptomatic GERD: The recommended adult oral dose is 20 mg once daily for 4 weeks. If symptoms do not resolve completely after 4 weeks, an additional course of treatment may be considered.
vi) Maintenance of healing of erosive or ulcerative GERD: It is indicated for maintaining healing and reduction in relapse rates of heartburn symptoms in patients with erosive or ulcerative GERD maintenance. Controlled studies do not extend beyond 12 months.
vii) Prevention or treatment of NSAID-induced ulcers: 20 mg tablet once daily, in patients receiving treatment with NSAIDs.
viii) Zollinger-Ellison Syndrome: The recommended adult oral starting dose is 60 mg once a day. Doses should be adjusted to individual patient needs and should continue for as long as clinically indicated. Some patients may require divided doses. Doses up to 100 mg once daily and 60 mg twice daily have been administered.
ix) Paediatric GERD: Treatment of GERD in Pediatric Patients 1 to 11 Years of Age: The recommended dosage for pediatric patients 1 to 11 years of age by body weight is:
• Less than 15 kg: 5 mg once daily for up to 12 weeks with the option to increase to 10 mg if inadequate response.
• 15 kg or more: 10 mg once daily for up to 12 weeks.
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.
Discuss with your doctors and tell them feedback about this medicine.
There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.
Pack Size & Price
Price : ৳
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