Precautions and warnings

Injecting immunoglobulin into a vein, when it is meant for muscle injection, can sometimes cause a sudden drop in blood pressure that looks like an allergic reaction. Therefore, immunoglobulin should only be injected into a muscle. Before giving the injection, pull back the plunger of the syringe to make sure the needle is not in a blood vessel. It is best to give intramuscular injections in the deltoid muscle of the upper arm or the side of the thigh. Avoid using the buttocks because there is a risk of damaging the sciatic nerve.

Taking antibiotics to prevent tetanus (chemoprophylaxis) is not practical or helpful for wound care. Proper wound cleaning, removing dead tissue if needed, and making sure the person is properly vaccinated are more important. Whether someone needs a tetanus shot (tetanus toxoid), with or without tetanus immune globulin (TIG), depends on how clean the wound is and the person’s history of tetanus shots. Tetanus almost never occurs in people who have completed their initial series of tetanus vaccinations.

Drug Interactions

May reduce the efficacy of live vaccines.

Contraindications

People who have IgA deficiency, especially if they also have antibodies against IgA, may be more likely to have allergic reactions to medicines that contain immunoglobulins (Ig) or similar proteins.

Mode of actions

Tetanus immunoglobulin is given to protect people from tetanus by providing immediate, short-term immunity.

Dosage & Administration

Adults and children 7 years and older: 250 units(1 ml) should be given by deep intramuscular injection .
At the same time, but in a different extremity and with a separate syringe, active immunization with adsorved tetanus vaccine should be administered.

Children less than 7 years old: In small children the routine prophylactic dose may be calculated by the body weight (4.0 units/kg).

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

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