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Axim 125mg (Tablet)

Manufactured by: Aristopharma Limited

Cefuroxime Similar medicine

Axim is indicated for

  • Pharyngitis
  • Acute otitis media
  • Lyme disease
  • Susceptible infections
  • Sinusitis
  • Otitis media
  • Skin
  • skin structure infections
  • Tonsillitis
  • Respiratory tract infections
  • Acute Maxillary Sinusitis
  • Urinary tract infections
  • Acute bacterial exacerbation of chronic bronchitis
  • Surgical Prophylaxis

Precautions and warnings

Discuss your medical history with your doctor before using this drug, especially if you have severe renal illness, pregnancy, a mother who breastfeeds her infant, penicillin hypersensitivity, liver disease, or poor nutrition.

This medication may cause dizziness or drowsiness. You may become dizzy or sleepy if you consume alcohol or cannabis. Do not drive, operate machinery, or engage in any other activity that requires attentiveness until you are sure you can do so safely. Limit your intake of alcoholic beverages. If you use marijuana, talk to your doctor.

Cefuroxime may impair the effectiveness of live bacterial vaccinations such as the typhoid vaccine. Unless your doctor advises otherwise, do not get any vaccines or vaccinations while taking this drug.

When administering this medication to the elderly, exercise caution because they may be more susceptible to its side effects.

Side-effects

  • Large doses can cause cerebral irritation
  • convulsions; nausea
  • vomiting
  • diarrhoea
  • GI disturbances; erythema multiforme
  • Stevens-Johnson syndrome
  • epidermal necrolysis. Potentially Fatal: Anaphylaxis
  • nephrotoxicity
  • pseudomembranous colitis.

Drug Interactions

Certain lab tests may be affected by this medicine. Certain diabetic urine testing kits, such as cupric sulfate-type, may produce false-positive findings, and certain blood glucose tests may produce false-negative results. Strong-acting diuretics, such as furosemide and aminoglycosides, may have a greater nephrotoxic effect. Oral anticoagulants may be improved by taking this supplement. It's possible that OCs' efficacy will be reduced. Cefuroxime excretion is prolonged by probenecid, resulting in a higher peak serum level.

Contraindications

Hypersensitivity to the active ingredient to cephalosporins.

Mode of actions

Cefuroxime binds to one or more penicillin-binding proteins (PBPs), which inhibits the last transpeptidation stage of peptidoglycan formation in bacterial cell walls, halting biosynthesis and causing bacterial cell death.

Dosage & Administration

Adult: PO Uncomplicated UTI 125 mg twice daily.
Resp tract infections 250-500 mg twice daily.
Uncomplicated gonorrhoea W/ oral probenecid: 1 g as a single dose.
IV Meningitis 3 g 8 hrly.
IM Gonorrhoea W/ oral probenecid: 1.5 g as a single dose.
IV/IM Surgical prophylaxis 1.5 g IV per-op, then 750 mg IM 8 hrly for up to 24-48 hr.
Susceptible infections 750 mg 8 hrly, up to 1.5 g 6-8 hrly for severe infections.

Children (above 3 months of age): 30 - 100 mg/kg/day given in 3 or 4 equally divided doses. A dose of 60mg/kg/day is appropriate for most infections.

Neonate: 30 - 100 mg/kg/day given in 2 or 3 equally divided doses.

Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid.
CrCl (ml/min)
10-20 750 mg bid.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.

Discuss with your doctors and tell them feedback about this medicine.

There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.

Pack Size & Price

10's pack Price : ৳150

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There are few similar medicines of Axim are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.