Arlin 600mg (Tablet)
Manufactured by: Beximco Pharmaceuticals Ltd.
Linezolid Similar medicine
Arlin is indicated for
- Community-acquired pneumonia
- Skin
- skin structure infections
- Nosocomial pneumonia
Precautions and warnings
Preexisting myelosuppression, renal impairment (CrCl < 30ml/min), uncontrolled hypertension, phaeochromocytoma, carcinoid syndrome, untreated hyperthyroidism, chronic infection, history of seizures, bipolar depression, schizophrenia or acute confusional states. Pregnancy and lactation. Monitor complete blood counts weekly. Give after haemodialysis. Not known if linezolid or metabolites removed during peritoneal dialysis.
This medication should not be used by people who already have bone marrow problems, severe kidney issues (with a creatinine clearance less than 30ml/min), uncontrolled high blood pressure, pheochromocytoma, carcinoid syndrome, untreated overactive thyroid, chronic infections, or a history of seizures, bipolar disorder, schizophrenia, or sudden confusion. It should also not be used during pregnancy or breastfeeding. Blood counts should be checked every week. Give the dose after haemodialysis. It is not known whether linezolid or its breakdown products are removed by peritoneal dialysis.
Side-effects
- Diarrhoea (antibiotic associated colitis reported)
- headache
- nausea
- vomiting
- constipation
- abnormal liver function tests
- fever
- vaginal
- oral candidiasis
- skin rash
- pruritus
- dizziness
- insomnia
- anaemia
- tongue discoloration
- taste disturbance
- lactic acidosis
- optic
- peripheral neuropathy (particularly if used > 28 days). Potentially Fatal: Reversible myelosuppression including anaemia
- leukopenia
- pancytopenia
- thrombocytopenia (particularly if using > 10-14 days)
- transient ischaemic attacks
- renal failure
- Stevens-Johnson syndrome.
Drug Interactions
Rifampicin and phenytoin can lower the levels of this medication in your blood. Using it with insulin or oral diabetes medicines may cause low blood sugar. Taking tramadol with it may raise the risk of seizures.
**Serious Risks:**
There is a high risk of a dangerous condition called serotonin syndrome if taken together with MAOIs, TCAs, SNRIs, or other drugs that increase serotonin (such as bupropion, vilazodone, mirtazapine, amoxapine, buspirone, maprotiline, meperidine, trazodone, or nefazodone). Blood pressure can rise significantly if used with certain drugs like vasopressors (epinephrine, norepinephrine), sympathomimetics (pseudoephedrine), or drugs that increase dopamine (dopamine, dobutamine).
Mode of actions
Linezolid is a type of antibiotic known as an oxazolidinone. It works by stopping bacteria from making proteins they need to grow. Linezolid is effective against certain gram-positive bacteria, including those that are resistant to other antibiotics like vancomycin-resistant enterococci and MRSA. However, it does not work well against gram-negative bacteria.
Dosage & Administration
Adults and Adolescents (12 Years and Older): PO Uncomplicated skin infections 400 mg 12 hrly for 10-14 days.
PO/IV Community-acquired pneumonia; Complicated skin and skin structure infections; Nosocomial pneumonia 600 mg 12 hrly for 10-14 days.
For Pediatric Patients (Birth through 11 Years of Age):
• Complicated skin and skin structure infections & Community-acquired pneumonia, including concurrent bacteremia: 600 mg IV or oral b.i.d. for 10 to 14 days.
• Vancomycin-resistant Enterococcus faecium infections, including concurrent bacteremia: 600 mg IV or oral b.i.d.for 14-28.
Neonates < 7 days: Most pre-term neonates < 7 days of age (gestational age < 34 weeks) have lower systemic linezolid clearance values and larger AUC values than many full-term neonates and older infants. These neonates should be initiated with a dosing regimen of 10 mg/kg every 12 hours. Consideration may be given to the use of 10 mg/kg in every eight hours regimen in neonates with a sub-optimal clinical response. All neonatal patients should receive 10 mg/kg t.i.d. by 7 days of life.
Methicillin-resistant Staphylococcus aureus infections; Vancomycin-resistant enterococci infections 600 mg 12 hrly. Treatment duration for vancomycin-resistant enterococci: 14-28 day.
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.
Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.
This medicine passes into breast milk. Talk to your doctor before breastfeeding.
Pack Size & Price
20's pack Price : ৳1700
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