Dermus (Ointment)
Manufactured by: Ibn Sina Pharmaceutical Ind. Ltd.
Tacrolimus 0.1%, 0.03% Topical Similar medicine
Dermus is indicated for
- Dermatitis atópica
- Dermatitis alérgica de contacto
- Eczema severo
- Psoriasis
- Alopecia areata
- Pioderma gangrenoso
- Lupus eritematoso cutáneo
- Dermatomiositis
- Dermatitis seborreica
- Rosácea
- Liquen plano
- Pénfigo vulgar
- Vitíligo
- Enfermedad de injerto contra huésped
- Ictiosis.
Precautions and warnings
Se debe tener precaución al utilizar la pomada de tacrolimus para tratar a pacientes con dermatitis atópica que probablemente sufran infecciones de la piel. No se ha demostrado la seguridad de la pomada de tacrolimus en personas con enrojecimiento generalizado de la piel (eritrodermia generalizada).
Side-effects
- La pomada de tacrolimus aplicada tópicamente tiene muy pocos y raros efectos secundarios
- como ardor en la piel
- prurito
- síntomas similares a los de la gripe
- reacciones alérgicas
- eritema cutáneo
- infecciones cutáneas
- dolor de cabeza
- etc.
Drug Interactions
Tacrolimus puede ser más dañino para los riñones si se toma con otros medicamentos como ciclosporina, aminoglucósidos, anfotericina B, cisplatino, AINE, vancomicina, cotrimoxazol, aciclovir o ganciclovir. También existe un mayor riesgo de niveles altos de potasio cuando se usa con diuréticos ahorradores de potasio. Algunos medicamentos, como los antimicóticos azólicos, los bloqueadores de los canales de calcio, la cimetidina, el danazol, los inhibidores de la proteasa del VIH, los antibióticos macrólidos y la metoclopramida, aumentan los niveles de tacrolimus en la sangre, lo que puede aumentar los efectos secundarios. Por otro lado, fármacos como los antiácidos, la rifampicina, la rifabutina, la caspofungina, la fenitoína, el fenobarbital y la carbamazepina pueden reducir los niveles de tacrolimus, haciéndolo menos eficaz. Tomar sirolimus y tacrolimus juntos puede reducir los niveles de ambos fármacos.
Contraindications
La pomada de tacrolimus no debe ser utilizada por personas alérgicas al tacrolimus o a cualquier otro ingrediente de la pomada.
Mode of actions
El tacrolimus actúa impidiendo que los linfocitos T (un tipo de célula inmunitaria) se activen, aunque su método exacto no se comprende completamente. Se adhiere a ciertas proteínas dentro de las células llamadas inmunofilinas, como la proteína de unión a FK-12 (FKBP-12). Esta conexión crea complejos que bloquean la creación de proteínas de señalización (citocinas) a través de una vía llamada calcineurina. Al bloquear la calcineurina, el tacrolimus impide que las células T se activen prematuramente, lo que conduce a una reducción de la actividad inmunitaria (inmunosupresión).
Dosage & Administration
Aplique una fina capa de pomada de Tacrolim en las áreas de la piel afectadas dos veces al día y frote suave y completamente. El tratamiento debe continuar durante una semana después de la desaparición de los signos y síntomas de la dermatitis atópica. No se ha evaluado la seguridad de la pomada de Tacrolim bajo oclusión, que puede promover la exposición sistémica. La pomada de tacrolim no debe usarse con apósitos oclusivos.
Pregnancy & Lactation
Aunque los estudios de reproducción en animales han demostrado un efecto adverso en el feto y no existen estudios adecuados y bien controlados en mujeres embarazadas, durante el embarazo este medicamento se puede utilizar sólo cuando sea definitivamente necesario a pesar de los riesgos potenciales.
Las madres con un bebé recién nacido que han usado este medicamento durante los últimos 3 meses de embarazo rara vez presentan síntomas que incluyen somnolencia, rigidez o temblores musculares, problemas para alimentarse o respirar, y llanto constante. Si nota alguno de estos síntomas en su bebé, especialmente durante el primer mes, informe al médico de inmediato.
Este medicamento pasa a la leche materna. Hable con su médico antes de amamantar.
Pack Size & Price
5gm tube/10gm tube Price : ৳80/150
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