Derfin 250mg (Tablet)
Manufactured by: Alco Pharma Limited
Terbinafine Similar medicine
Derfin is indicated for
- Tinea pedis
- Tinea cruris
- Tinea corporis
- Dermatophytosis
- Nail infections
Precautions and warnings
If you have existing liver or kidney problems, or if you are pregnant, special care is needed. Make sure to have your liver function tested before starting oral treatment.
Side-effects
- Anorexia
- nausea
- abdominal pain
- taste disturbances
- diarrhoea
- rash
- urticaria. Potentially Fatal: Liver failure
- Stevens-Johnson syndrome
- neutropaenia.
Drug Interactions
Drugs that are broken down by the enzyme CYP450 2D6 may have higher levels when taken with terbinafine. Rifampicin can lower the amount of terbinafine in the body, while cimetidine can increase terbinafine levels.
Contraindications
Hypersensitivity, active or chronic liver disease, lactation.
Mode of actions
Terbinafine works by blocking squalene epoxidase, an important enzyme that fungi need to make sterols for their cell walls. This prevents the fungus from producing ergosterol, a key component of its cell wall, leading to the death of the fungal cells. Terbinafine is effective at killing dermatophytes (a type of fungus that causes skin infections) and some types of yeast.
Dosage & Administration
Oral
Dermatophytosis
Adult: 250 mg once daily for 2-4 wk in tinea cruris, 6 wk for tinea pedis, 4 wk for tinea corporis and 6-12 wk for nail infections.
Child: 10-20 kg: 62.5 mg; 20-40 kg: 125 mg; >40 kg: 250 mg. Doses to be taken once daily. Treatment is usually given for 2 wk for tinea capitis; 2-4 wk for tinea cruris; 4 wk for tinea corporis; 6 wk in tinea pedis; 6-12 wk for nail infections.
Renal impairment:
CrCl (ml/min)
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.
Discuss with your doctors and tell them feedback about this medicine.
There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.
Pack Size & Price
10's pack Price : ৳350
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