Precautions and warnings

Cirrhosis and low Na diets; patients with recent GI haemorrhage; chronic renal impairment; CHF; oedema; cirrhosis and low Na diets; patients with recent GI haemorrhage To avoid drug interactions, use 2-3 hours before or after another medication. Lactation and pregnancy.

Drug Interactions

Aluminium Hydroxide: Absorption is improved when combined with citrates or ascorbic acid. Allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine, phenytoin, phenothia.

Tetracyclines and biphosphonates are less absorbed when magnesium hydroxide is present. After about 2 hours, these and other medications should be administered separately.

Simethicon: None well documented.

Contraindications

Hypersensitivity to aluminium salts.

Mode of actions

Aluminum hydroxide (AlCl3 salt + water) neutralizes stomach hydrochloride and raises gastric pH.

Magnesium hydroxide promotes bowel evacuation by producing osmotic fluid retention, causing the colon to distend with increased peristaltic activity; when combined with hydrochloric acid, it creates magnesium chloride.

Simethicone reduces the surface tension of gas bubbles, dispersing and preventing gas pockets in the GI system.

Dosage & Administration

Adult: PO Antacid Up to 1 g/day. Hyperphosphataemia in chronic renal failure Up to 10 g/day in divided doses w/ meals.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

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