Precautions and warnings

This medicine should be used with caution in children, the elderly, and people with kidney or liver problems, porphyria, epilepsy, Parkinson’s disease, or a history of depression. It may affect your ability to drive or operate machinery. Use during pregnancy or breastfeeding should be closely monitored. Patients on long-term treatment should be checked regularly. There is a higher risk of developing tardive dyskinesia (involuntary movements) with high doses or prolonged use.

Drug Interactions

Combining this medicine with other drugs that slow down the central nervous system (CNS depressants) can make sedative effects stronger. Stomach-related side effects may be blocked by medicines like antimuscarinics and opioids. This medicine can lower how much digoxin your body absorbs but increase the absorption of drugs like ciclosporin, levodopa, aspirin, and paracetamol. It can reduce the effect of bromocriptine, used to lower prolactin levels. It also blocks an enzyme called cholinesterase, which can make the muscle-relaxing effects of suxamethonium and mivacurium last longer.
**Warning:** Mixing this drug with sertraline (an SSRI) can cause dangerous serotonin syndrome.

Contraindications

Bleeding in the digestive tract, blockages or holes in the intestines, pheochromocytoma (a rare tumor), and a history of seizures.

Mode of actions

Metoclopramide helps the upper part of the digestive system move food more efficiently and speeds up how quickly the stomach empties, without changing the amount of stomach, bile, or pancreatic fluids. It also makes the muscles in the intestine move food faster and strengthens the muscle at the end of the esophagus, preventing acid reflux. Additionally, metoclopramide blocks dopamine receptors in the brain and may also block certain serotonin receptors (5-HT3).

Dosage & Administration

Adult: PO Diabetic gastric stasis 10 mg 4 times/day. Usual duration: 2-8 wk. Nausea and vomiting associated w/ cancer chemotherapy or radiotherapy 2 mg/kg 1 hr before start of treatment. Repeat dose 3 times at 2-hrly intervals. May repeat 2 additional doses at 3-hrly intervals if needed. Max: 12 mg/kg/day. Gastro-oesophageal reflux disease 10-15 mg up to 4 times/day, depending on severity of symptoms. Delayed emesis following chemotherapy 20-40 mg 2-4 times/day for 3-4 days.

IV Nausea and vomiting associated w/ cancer chemotherapy Highly emetogenic regimens: 2 mg/kg 30 mins before start of treatment. Repeat twice at 2-hrly intervals. Less emetogenic regimens: 1 mg/kg. If vomiting is not well-controlled, 3 additional doses at 2 mg/kg/dose 3-hrly. If vomiting is well-controlled w/ the 1st 3 doses, may reduce dose to 1 mg/kg 3-hrly for 3 additional doses. Intubation of the small intestine; Premed for radiologic examination of the upper GI tract 10 mg as a single direct inj.

IV/IM Diabetic gastric stasis 10 mg 4 times/day. Convert to PO when possible. Usual duration: 2-8 wk. IM Post-op nausea and vomiting 10 mg near the end of the procedure. Repeat 4-6 hrly when needed.

Renal impairment: Moderate to severe: Reduce dose by at least 50%
CrCl (ml/min)

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.

Discuss with your doctors and tell them feedback about this medicine.

There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.

Pack Size & Price