Precautions and warnings

Bipolar disorder, pregnancy, lactation in the elderly, CVS disease, renal or hepatic failure, epilepsy, thyroid dysfunction, and diabetes mellitus Urinary retention, prostatic hyperplasia, chronic constipation, angle-closure glaucoma, and phaeochromocytoma are all things to avoid. Keep an eye out for indicators of clinical deterioration, suicidality, or a change in behavior. It's possible that electro-convulsive therapy will enhance the hazards. It's possible that it'll affect your capacity to drive or operate machinery.

Drug Interactions

SSRIs, TCAs, triptans, fentanyl, lithium, and tramadol all increase the risk of serotonin syndrome. Barbiturates, rifampicin, and other anticonvulsants may lower plasma levels. Methylphenidate, cimetidine, antipsychotics, and calcium channel blockers may all raise plasma levels. Along with thyroid hormones, it may cause cardiac arrhythmias. Debrisoquine, guanethidine, and clonidine's antihypertensive effects may be reduced. Epinephrine and norepinephrine's pressor effects may be enhanced. Antiarrhythmics (e.g. amiodarone or quinidine), antihistamines (astemizole, terfenadine), some antipsychotics (pimozide, sertindole, and thioridazine), sotalol, cisapride, and halofantrine) may increase the incidence of ventricular arrhythmias.

MAOIs, linezolid, and methylene blue all increase the risk of serotonin syndrome, which can be fatal.

Contraindications

Hypersensitivity; usage of MAO inhibitors during the prior 14 days; acute post-MI recovery phase Use with cisapride at the same time.

Mode of actions

Amitriptyline is a tricyclic antidepressant that has the dibenzo. It blocks the neuronal reuptake of norepinephrine and serotonin, increasing synaptic concentrations of serotonin and/or norepinephrine in the CNS.

Dosage & Administration

Adult: PO Depression Initial:50-75 mg/day; up to 150 mg/day if needed. Max: 300 mg/day in severe cases.
Child: Adolescent: Initially, 25-50 mg/day as a single dose (at bedtime) or in divided doses.
Elderly: Initially, 25-50 mg/day as a single dose (at bedtime) or in divided doses.

Neuropathic pain Initial: 10-25 mg/day at night, up to 75 mg/day if needed.
Migraine prophylaxis Initial: 10 mg/day at night. Maintenance: 50-75 mg/day at night.
Nocturnal enuresis
Child: 6-10 yr 10-20 mg/day; 11-16 yr 25-50 mg/day. All doses to be given at bedtime. Max duration: 3 mth.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

Pack Size & Price