Precautions and warnings

Epilepsy, congestive heart failure (CHF), kidney problems, liver cirrhosis, high blood pressure, swelling (oedema), eclampsia, and high aldosterone levels (aldosteronism). During treatment for acidosis, regularly check blood electrolyte levels and acid-base balance. Use with caution during pregnancy and breastfeeding.

Drug Interactions

This substance can make drugs like amphetamines, ephedrine, pseudoephedrine, flecainide, quinidine, and quinine more toxic. It can also lower the effectiveness of lithium, chlorpropamide, and salicylates because it helps the body remove them faster. Additionally, it might change how some medicines are absorbed because it increases the stomach’s pH (makes the stomach less acidic).

Contraindications

Alkalosis caused by metabolism or breathing problems; high levels of sodium in the blood; severe fluid buildup in the lungs; low calcium levels; and low stomach acid.

Mode of actions

Sodium bicarbonate increases the pH of blood and urine by breaking down and releasing bicarbonate ions. These ions help balance out excess hydrogen ions, reducing acidity. It also helps neutralize stomach acid by producing carbon dioxide.

Dosage & Administration

Adult: PO Urine alkalinisation Up to 10 g/day in divided doses w/ sufficient fluid intake. Chronic metabolic acidosis >4.8 g/day as needed. Dyspepsia 1-5 g when needed.

IV Severe metabolic acidosis By slow inj of a hypertonic soln >8.4% or by continuous infusion of a weaker soln, usually 1.26% .

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

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