Zixin 500mg (Tablet)
Manufactured by: Opso Saline Ltd.
Azithromycin Similar medicine
Zixin is indicated for
- Bakterielle Infektionen
- bakterielle Endokarditis
- Typhus
- ambulant erworbene Pneumonie
- unkomplizierte Gonorrhoe
- Streptokokken-Pharyngitis/Tonsillitis
- COPD
- akute bakterielle Sinusitis
- akute Mittelohrentzündung
- unkomplizierte Harnwegsinfektion
- unkomplizierte Gonorrhoe
- PID
- nicht-Gonokokken-Urethritis
- Schanker
- akute Salmonellose
- Zervizitis
- Babesiose
- Chlamydieninfektionen
- entzündliche Erkrankungen des Beckens
- PID
- Reisedurchfall
Precautions and warnings
Ein verlängertes QT-Intervall, niedrige K- oder Mg-Blutspiegel, eine langsame Herzfrequenz und Medikamente zur Behandlung unregelmäßiger Herzrhythmen können bei Patienten das Risiko für Torsades de pointes und tödliche Herzrhythmusstörungen erhöhen. Sowohl die Leber- als auch die Nierenfunktion sind beeinträchtigt. Stillzeit und Schwangerschaft. Zu überwachende Parameter Leberfunktionstests, Blutbild und Differentialdiagnose werden empfohlen.
Side-effects
- Magen-Darm-Störungen
- Sehstörungen und Reizungen; Taubheit
- Schwindel
- Kopfschmerzen
- Müdigkeit
- Anorexie
- Parästhesie
- Geschmacksstörung
- verstopfte Nase
- Sinusitis
- Gesichtsschwellung
- periokulare Schwellung
- Pruritus
- Hautausschlag
- Urtikaria
- Arthralgie
- Vaginitis; Schmerzen an der Injektionsstelle
- Entzündung; verringerte Lymphozytenzahl und Bikarbonat im Blut
- erhöhte Eosinophilenzahl
- erhöhte Transaminasewerte und/oder erhöhte Werte der alkalischen Phosphatase. Potenziell tödlich: Angioödem und cholestatischer Ikterus.
Drug Interactions
Die Serumkonzentrationen von Digoxin, Ciclosporin, Terfenadin, Hexobarbital und Phenytoin sind ebenfalls erhöht. Antazida, die Aluminium und Magnesium enthalten, verringern die Absorptionsrate. Wahrscheinlicher ist eine Mutterkornvergiftung.
Pimozid erhöht das Risiko einer Kardiotoxizität, die tödlich sein kann.
Contraindications
Es ist bekannt, dass Azithromycin, Erythromycin oder andere Makrolid- oder Ketolid-Antibiotika Überempfindlichkeit hervorrufen. Zusammen mit Pimozid wird die gleichzeitige Anwendung empfohlen. Die frühere Anwendung von Azithromycin wurde mit cholestatischem Ikterus und Leberfunktionsstörungen in Verbindung gebracht.
Mode of actions
Azithromycin ist ein Azalid-Antibiotikum, das halbsynthetisch ist. Es stört die RNA-abhängige Proteinsynthese im Schritt der Kettenverlängerung, indem es sich an die ribosomale 50er-Untereinheit empfindlicher Organismen bindet und die Transpeptidierung blockiert.
Dosage & Administration
Erwachsener: PO Infektionen des Resp-Trakts; Haut- und Weichteilinfektionen 500 mg einmal täglich für 3 Tage. Schanker; Nicht-Gonokokken-Zervizitis/Urethritis aufgrund von Chlamydia trachomatis; Unkomplizierte Genitalinfektionen durch Chlamydia trachomatis 1 g als Einzeldosis.
Prophylaxe disseminierter MAC-Infektionen 1,2 g einmal wöchentlich. Behandlung oder Sekundärprophylaxe: 500 mg einmal täglich mit anderen Antimykobakterien.
Unkomplizierter Gonorrhoe 2 g als Einzeldosis. Granuloma inguinale Initial: 1 g, dann 500 mg/Tag bis zur vollständigen Abheilung aller Läsionen.
Aktive Immunisierung gegen Typhus, verursacht durch Salmonella typhi, 1 g einmal täglich für 5 Tage.
IV. Ambulant erworbene Pneumonie: 500 mg als einzelne intravenöse Tagesdosis für 2 Tage, dann 500 mg einzelne orale Dosis täglich, um die 7–10-tägige Therapie abzuschließen.
Entzündliche Erkrankungen des Beckens: 500 mg als einzelne intravenöse Tagesdosis für 1–2 Tage, dann 250 mg einzelne orale Dosis täglich zur Vervollständigung einer 7-tägigen Therapie.
Kind: >6 Monate 10 mg/kg; 15-25 kg: 200 mg; 26-35 kg: 300 mg; 36-45 kg: 400 mg. Alle Dosen müssen 3 Tage lang einmal täglich eingenommen werden.
Pregnancy & Lactation
Obwohl tierexperimentelle Reproduktionsstudien eine nachteilige Wirkung gezeigt haben, konnte das Risiko für den Fötus manchmal nicht nachgewiesen werden, und es gibt keine ausreichenden und gut kontrollierten Studien bei schwangeren Frauen. Während der Schwangerschaft kann dieses Arzneimittel jedoch nur dann angewendet werden, wenn dies unbedingt erforderlich ist.
Besprechen Sie dies mit Ihren Ärzten und teilen Sie ihnen Feedback zu diesem Arzneimittel mit.
Es liegen keine spezifischen Informationen darüber vor, ob dieses Arzneimittel über die Muttermilch auf das Baby übertragen wird. Besprechen Sie dies mit Ihrem Arzt, bevor Sie stillen.
Pack Size & Price
Price : ৳
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