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Lijenta 5 mg (Tablet)

Manufactured by: NIPRO JMI Pharma Limited

Linagliptin Similar medicine

Lijenta is indicated for Type 2 Diabetes Mellitus

Precautions and warnings

Concomitant use w/ sulphonylureas which are known to cause hypoglycemia; dose reduction of sulphonylureas may be considered. May affect ability to drive or operate machinery. Childn. Elderly >75 yr. Pregnancy & lactation.

Side-effects

Hypoglycaemia. Uncommonly, nasopharyngitis, hypersensitivity, cough.
Hypoglycemia was more commonly reported in patients treated with the combination and sulfonylurea compared with those treated with the combination of placebo and sulfonylurea

Drug Interactions

Decreased steady-state AUC & Cmax w/ rifampicin.

Contraindications

Patients with a history of a hypersensitivity reaction to linagliptin, such as urticaria, angioedema, or bronchial hyperreactivity. Type 1 DM. Treatment of diabetic ketoacidosis.

Mode of actions

Dipeptidyl peptidase 4 (DPP-4) inhibitor; increases and prolongs incretin hormone activity which is inactivated by DPP-4 enzyme.

Incretins regulate glucose homeostasis by increasing insulin synthesis and release from pancreatic beta cells and reducing glucagon secretion from pancreatic alpha cells .

Dosage & Administration

Adults: Recommended Dose: 5 mg once daily.

When linagliptin is added to metformin, the dose of metformin should be maintained and linagliptin administered concomitantly.

When linagliptin is used in combination with a sulphonylurea, a lower dose of the sulphonylurea may be considered to reduce the risk of hypoglycaemia.

Special Population: Renal Impairment: No dose adjustment.
Hepatic Impairment: Pharmacokinetics studies suggest that no dose adjustment is required for patients with hepatic impairment.
Elderly: No dose adjustment is necessary based on age. However, clinical experience in patients >75 years is limited.
Children: The safety and efficacy of linagliptin in paediatric population has not yet been established. No data are available.
Administration:It can be taken with or without a meal at any time of the day.

Pregnancy & Lactation

Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.