Vitilimus 100 mg/100 gm (Ointment)
Manufactured by: Unimed & Unihealth Manufacturers Ltd.
Tacrolimus 0.1%, 0.03% Topical Similar medicine
Vitilimus is indicated for
- Dermatitis atopik
- Dermatitis kontak alergi
- Eksim parah
- Psoriasis
- Alopecia areata
- Pyoderma gangrenosum
- Lupus eritematosus kulit
- Dermatomiositis
- Dermatitis seboroik
- Rosacea
- Lichen Planus
- Pemfigus Vulgaris
- Vitiligo
- Penyakit Graft-Versus-Host
- Ichthyosis.
Precautions and warnings
Saat menggunakan salep Tacrolimus untuk mengobati pasien dengan dermatitis atopik yang cenderung terkena infeksi kulit, diperlukan kehati-hatian. Keamanan salep Tacrolimus belum terbukti untuk orang dengan kulit kemerahan yang meluas (generalized erythroderma).
Side-effects
- Salep Tacrolimus yang dioleskan secara topikal memiliki efek samping yang sangat sedikit dan jarang termasuk kulit terbakar
- pruritus
- gejala mirip flu
- reaksi alergi
- eritema kulit
- infeksi kulit
- sakit kepala
- dll.
Drug Interactions
Tacrolimus bisa lebih berbahaya bagi ginjal jika dikonsumsi dengan obat lain seperti ciclosporin, aminoglikosida, amfoterisin B, cisplatin, NSAID, vankomisin, kotrimoksazol, asiklovir, atau gansiklovir. Ada juga risiko tinggi kadar kalium tinggi bila digunakan dengan diuretik hemat kalium. Beberapa obat—seperti antijamur azol, penghambat saluran kalsium, simetidin, danazol, penghambat protease HIV, antibiotik makrolida, dan metoklopramid—meningkatkan kadar tacrolimus dalam darah, yang dapat meningkatkan efek samping. Di sisi lain, obat-obatan seperti antasida, rifampisin, rifabutin, caspofungin, fenitoin, fenobarbital, dan karbamazepin dapat menurunkan kadar tacrolimus sehingga kurang efektif. Mengonsumsi sirolimus dan tacrolimus secara bersamaan dapat menurunkan kadar kedua obat tersebut.
Contraindications
Salep Tacrolimus tidak boleh digunakan oleh orang yang alergi terhadap Tacrolimus atau bahan lain dalam salep.
Mode of actions
Tacrolimus bekerja dengan menghentikan limfosit T (sejenis sel kekebalan) agar tidak aktif, meskipun metode pastinya belum sepenuhnya dipahami. Ia menempel pada protein tertentu di dalam sel yang disebut imunofilin, seperti FK binding protein-12 (FKBP-12). Koneksi ini menciptakan kompleks yang menghalangi pembentukan protein pemberi sinyal (sitokin) melalui jalur yang disebut kalsineurin. Dengan memblokir kalsineurin, tacrolimus mencegah sel T aktif lebih awal, yang menyebabkan berkurangnya aktivitas kekebalan (imunosupresi).
Dosage & Administration
Oleskan salep Tacrolim tipis-tipis ke area kulit yang terkena dua kali sehari dan gosok dengan lembut dan menyeluruh. Pengobatan harus dilanjutkan selama satu minggu setelah tanda dan gejala dermatitis atopik hilang. Keamanan salep Tacrolim dalam oklusi yang dapat menyebabkan paparan sistemik belum dievaluasi. Salep tacrolim tidak boleh digunakan dengan dressing oklusif.
Pregnancy & Lactation
Meskipun penelitian pada reproduksi hewan menunjukkan efek buruk pada janin dan belum ada penelitian yang memadai dan terkontrol dengan baik pada wanita hamil, namun selama kehamilan, obat ini dapat digunakan tepat ketika benar-benar diperlukan meskipun ada potensi risikonya.
Ibu dengan bayi baru lahir yang telah menggunakan obat ini selama 3 bulan terakhir kehamilan mungkin jarang mengalami gejala termasuk mengantuk, otot kaku atau gemetar, kesulitan makan atau bernapas, dan menangis terus-menerus. Jika Anda melihat gejala-gejala ini pada bayi Anda terutama pada bulan pertama, segera beri tahu dokter.
Obat ini masuk ke dalam ASI. Bicaralah dengan dokter Anda sebelum menyusui.
Pack Size & Price
Price : ৳
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