Vitilimus 100 mg/100 gm (Ointment)
Manufactured by: Unimed & Unihealth Manufacturers Ltd.
Tacrolimus 0.1%, 0.03% Topical Similar medicine
Vitilimus is indicated for
- Dermatite atópica
- Dermatite alérgica de contato
- Eczema grave
- Psoríase
- Alopecia areata
- Pioderma gangrenoso
- Lúpus eritematoso cutâneo
- Dermatomiosite
- Dermatite seborreica
- Rosácea
- Líquen plano
- Pênfigo vulgar
- Vitiligo
- Doença do enxerto contra o hospedeiro
- Ictiose.
Precautions and warnings
Ao usar pomada de tacrolimus para tratar pacientes com dermatite atópica com probabilidade de contrair infecções de pele, é necessário cautela. A segurança da pomada de Tacrolimus não foi comprovada em pessoas com vermelhidão generalizada da pele (eritrodermia generalizada).
Side-effects
- A pomada de Tacrolimus aplicada topicamente tem muito poucos e raros tipos de efeitos colaterais
- incluindo queimação na pele
- prurido
- sintomas semelhantes aos da gripe
- reações alérgicas
- eritema cutâneo
- infecções cutâneas
- dor de cabeça
- etc.
Drug Interactions
O tacrolimus pode ser mais prejudicial aos rins se tomado com outros medicamentos como ciclosporina, aminoglicosídeos, anfotericina B, cisplatina, AINEs, vancomicina, cotrimoxazol, aciclovir ou ganciclovir. Também existe um risco maior de níveis elevados de potássio quando usado com diuréticos poupadores de potássio. Alguns medicamentos – como antifúngicos azólicos, bloqueadores dos canais de cálcio, cimetidina, danazol, inibidores da protease do HIV, antibióticos macrólidos e metoclopramida – aumentam os níveis de tacrolimus no sangue, o que pode aumentar os efeitos colaterais. Por outro lado, medicamentos como antiácidos, rifampicina, rifabutina, caspofungina, fenitoína, fenobarbital e carbamazepina podem diminuir os níveis de tacrolimus, tornando-o menos eficaz. Tomar sirolimus e tacrolimus juntos pode diminuir os níveis de ambos os medicamentos.
Contraindications
A pomada de tacrolimus não deve ser usada por pessoas alérgicas ao tacrolimus ou a qualquer outro ingrediente da pomada.
Mode of actions
O tacrolimus atua impedindo que os linfócitos T (um tipo de célula imunológica) se tornem ativos, embora seu método exato não seja totalmente compreendido. Ele se liga a certas proteínas dentro das células chamadas imunofilinas, como a proteína de ligação ao FK-12 (FKBP-12). Essa conexão cria complexos que bloqueiam a criação de proteínas sinalizadoras (citocinas) através de uma via chamada calcineurina. Ao bloquear a calcineurina, o tacrolimus impede a ativação precoce das células T, o que leva à redução da atividade imunológica (imunossupressão).
Dosage & Administration
Aplique uma fina camada de pomada Tacrolim nas áreas afetadas da pele duas vezes ao dia e esfregue suave e completamente. O tratamento deve ser continuado durante uma semana após a eliminação dos sinais e sintomas da dermatite atópica. A segurança da pomada Tacrolim sob oclusão, que pode promover exposição sistêmica, não foi avaliada. A pomada de Tacrolim não deve ser usada com curativos oclusivos.
Pregnancy & Lactation
Embora estudos de reprodução animal tenham demonstrado um efeito adverso no feto e não existam estudos adequados e bem controlados em mulheres grávidas, mas durante a gravidez, este medicamento pode ser utilizado apenas quando definitivamente necessário, apesar dos riscos potenciais.
As mães com um bebê recém-nascido que usaram este medicamento durante os últimos 3 meses de gravidez raramente podem apresentar sintomas incluindo sonolência, rigidez ou tremores musculares, problemas de alimentação ou respiração, choro constante. Se você notar algum destes sintomas em seu bebê, especialmente durante o primeiro mês, informe o médico imediatamente.
Este medicamento passa para o leite materno. Converse com seu médico antes de amamentar.
Pack Size & Price
Price : ৳
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