Clopixol Depot 200mg/ml (Injection)
Manufactured by: H. Lundbeck & Co., A/S, Denmark
Zuclopenthixol Similar medicine
Clopixol Depot is indicated for
- Schizophrenia
- Psychoses
- Bipolar mania
Precautions and warnings
Problems with the liver and kidneys, heart conditions, a recent heart attack, irregular heartbeats, and very slow heart rate.
Side-effects
- Drowsiness
- blurred vision
- tachycardia
- nausea
- dizziness
- headache
- excitement
- postural hypotension
- hyperprolactinaemia
- sexual dysfunction
- ECG changes (prolongation of QT interval
- T wave changes)
- hyperthermia. Extrapyramidal symptoms may occur
- especially during the early phase of treatment; urinary frequency or incontinence; tardive dyskinesia. Potentially Fatal: Neuroleptic malignant syndrome
- blood dyscrasias.
Drug Interactions
Zuclopenthixol can make you feel more drowsy if you drink alcohol or take medicines that slow down your brain, like barbiturates or other sedatives. It can also make blood pressure medicines like guanethidine less effective. If you take zuclopenthixol together with metoclopramide or piperazine, you have a higher risk of movement problems (extrapyramidal symptoms). Using it with lithium or sibutramine increases the risk of serious damage to your nervous system. Taking other medicines that have anticholinergic effects with zuclopenthixol can cause stronger anticholinergic side effects (like dry mouth, blurred vision, constipation).
**Serious Risks:**
Zuclopenthixol can block the effects of medicines like apomorphine, levodopa, and other dopamine boosters, which can be dangerous. Taking zuclopenthixol with clozapine increases the risk of serious blood problems. There is also a higher chance of abnormal heart rhythms if you use zuclopenthixol with medicines that affect your heart’s rhythm (such as certain antiarrhythmics, erythromycin, or medicines that can lower your potassium levels, like thiazide diuretics).
Contraindications
Allergic reactions (hypersensitivity). People who are in a coma, such as those caused by alcohol, barbiturate, or opiate overdose; people with porphyria; and children.
Mode of actions
Zuclopenthixol strongly attaches to D1 and D2 receptors, as well as alpha-adrenoreceptors. It also has mild antihistamine effects and can block some serotonin activity.
Dosage & Administration
Adult: PO Psychoses Initial: 20-30 mg/day in divided doses. Maintenance: 20-50 mg/day. Max: 150 mg/day.
IM Acute psychosis As acetate ester: 150 mg, repeat if needed 2-3 days later. Max cumulative dose: 400 mg/course. Max number of inj: 4/course. Max duration: 2 wk.
Chronic psychosis As decanoate ester: Initial: 100 mg as test dose, followed after at least 1 wk by 200-500 mg or more, repeated at 1-4 wkly if needed. Max: 600 mg/wk. Inj >2 mL to be distributed between 2 inj sites.
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.
Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.
This medicine passes into breast milk. Talk to your doctor before breastfeeding.
Pack Size & Price
10 amp's pack Price : ৳4333.10
Similar medicine
Manufactured by: H. Lundbeck & Co., A/S, Denmark
Manufactured by: A/S Lundbeck Export DivisionLtd., Denmark
Manufactured by: H. Lundbeck & Co., A/S, Denmark
Click here to see more similar medicines
There are few similar medicines of Clopixol Depot are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
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