Arlin 400mg (Tablet)
Manufactured by: Beximco Pharmaceuticals Ltd.
Linezolid Similar medicine
Arlin is indicated for
- 社區型肺炎、皮膚及皮膚結構感染、院內肺炎
Precautions and warnings
先前有骨髓抑制、腎功能損害（CrCl < 30ml/min）、未控制的高血壓、嗜鉻細胞瘤、類癌症候群、未經治療的甲狀腺功能亢進、慢性感染、癲癇病史、雙相憂鬱、精神分裂症或急性精神錯亂狀態。 懷孕和哺乳期。 每週監測全血球計數。 血液透析後給予。 不知道腹膜透析期間利奈唑胺或代謝物是否被移除。
患有骨髓問題、嚴重腎臟問題（肌酸酐清除率低於 30 毫升/分鐘）、未受控制的高血壓、嗜鉻細胞瘤、類癌症候群、未經治療的甲狀腺功能亢進、慢性感染或有癲癇病史、雙相情感障礙、精神分裂症或突然精神錯亂的人不應該使用這種藥物。 它也不應該在懷孕或哺乳期間使用。 應每週檢查血球數。 血液透析後給予劑量。 目前尚不清楚利奈唑胺或其分解產物是否可以透過腹膜透析去除。
Side-effects
- 腹瀉（報告抗生素相關性結腸炎）、頭痛、噁心、嘔吐、便秘、肝功能檢查異常、發燒、陰道和口腔念珠菌病、皮疹、搔癢、頭暈、失眠、貧血、舌頭變色、味覺障礙、乳酸性酸中毒、視神經和周邊神經病變（特別是使用超過 28 天時）。 潛在致命：可逆性骨髓抑制，包括貧血、白血球減少、全血球減少和血小板減少（特別是使用> 10-14天）、短暫性腦缺血發作、腎衰竭、史蒂文斯-約翰遜症候群。
Drug Interactions
利福平和苯妥英可以降低血液中這種藥物的含量。 與胰島素或口服糖尿病藥物一起使用可能會導致低血糖。 與曲馬多一起服用可能會增加癲癇發作的風險。
**嚴重風險：**
如果與 MAOIs、TCA、SNRI 或其他增加血清素的藥物（如安非他酮、維拉佐酮、米氮平、阿莫沙平、丁螺環酮、馬普替林、哌替啶、曲唑酮或奈法唑酮）一起服用，則有很高的風險患上稱為血清素綜合徵的危險疾病。 如果與某些藥物一起使用，如血管加壓藥（腎上腺素、正腎上腺素）、擬交感神經藥（偽麻黃鹼）或增加多巴胺的藥物（多巴胺、多巴酚丁胺），血壓可能會顯著升高。
Mode of actions
利奈唑胺是一種稱為噁唑烷酮的抗生素。 它的作用是阻止細菌製造生長所需的蛋白質。 利奈唑胺對某些革蘭氏陽性細菌有效，包括對其他抗生素（如耐萬古黴素腸球菌和 MRSA）具有抗藥性的細菌。 然而，它對革蘭氏陰性菌效果不佳。
Dosage & Administration
成人及青少年（12 歲以上）：口服無併發症皮膚感染 400 毫克，每小時 12 次，持續 10-14 天。
PO/IV 社區型肺炎；複雜的皮膚和皮膚結構感染；院內肺炎 600 mg，每小時 12 次，持續 10-14 天。
對於兒科患者（出生至 11 歲）：
• 複雜的皮膚和皮膚結構感染和社區獲得性肺炎，包括併發菌血症：600 mg IV 或口服 b.i.d.持續 10 至 14 天。
• 耐萬古黴素屎腸球菌感染，包括併發菌血症：600 mg IV 或口服，每日兩次，持續 14-28 個月。
新生兒 < 7 天：與許多足月新生兒和較大嬰兒相比，大多數 < 7 天的早產新生兒（胎齡 < 34 週）具有較低的利奈唑胺全身清除率值和較大的 AUC 值。 這些新生兒應以每 12 小時 10 mg/kg 的給藥方案開始。 對於臨床反應不佳的新生兒，可考慮每 8 小時給藥 10 mg/kg。 所有新生兒患者應接受 10 mg/kg，t.i.d.至生命 7 天為止。
抗甲氧西林金黃色葡萄球菌感染；萬古黴素抗藥性腸球菌感染 600 mg，每 12 小時一次。 耐萬古黴素腸球菌的治療時間：14-28天。
Pregnancy & Lactation
儘管動物生殖研究顯示對胎兒有不良影響，並且在孕婦中沒有充分且良好對照的研究，但在懷孕期間，儘管存在潛在風險，但在確實需要時可以使用該藥物。
在懷孕最後 3 個月內使用這種藥物的新生兒母親可能很少會出現困倦、肌肉僵硬或顫抖、餵食或呼吸困難、持續哭泣等症狀。 如果您發現寶寶有任何這些症狀，尤其是在第一個月內，請立即告訴醫生。
這種藥物會進入母乳。 哺乳前請先諮詢您的醫生。
Pack Size & Price
20's pack Price : ৳1200
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